Platelets (Hardcover, 4)

Part One Platelet Biology 1. The Evolution of Mammalian Platelets 2. Megakaryocyte Development and Platelet Formation 3. Platelet Structure 4. The Platelet Cytoskeleton 5. Platelet Genomics and Proteomics 6. Platelet Receptors 7. The Glycoprotein Ib-IX-V 8. Integrin aIIbb3 9. Thrombin Receptors 10. The Platelet P2 Receptors 11. PECAM-1 12. P-Selectin/PSGL-1 and Other Interactions Between Platelets, Leukocytes, and Endothelium 13. Inhibition of Platelet Function by the Endothelium 14. Platelet Polymorphisms 15. Platelet Secretion 16. Signal Transduction during Platelet Plug Formation 17. Outside-In Signaling by Integrin aIIbb3 18. Platelet Thrombus Formation in Flowing Blood 19. Interactions between Platelets and the Coagulation System 20. Platelet-Derived Microparticles 21. The Role of Platelets in Fibrinolysis 22. Platelet Function in the Newborn

Part Two Tests of Platelet Function 23. Clinical Tests of Platelet Function 24. Platelet Counting 25. The Bleeding Time 26. Platelet Aggregation 27. The VerifyNow System 28. The Platelet Function Analyzer (PFA)-100 29. Impact Cone and Plate(let) Analyzer 30. Flow Cytometry 31. Thromboxane Generation 32. Perfusion Chambers 33. Animal Models 34. Real-Time in Vivo Imaging of Platelets during Thrombus Formation

Part Three The Role of Platelets in Disease 35. Atherothrombosis and Coronary Artery Disease 36. Central Nervous System Ischemia 37. Peripheral Vascular Disease 38. Diabetes Mellitus 39. Inflammation 40. Antimicrobial Host Defense 41. Angiogenesis 42. Tumor Growth and Metastasis 43. Alzheimer’s Disease 44. Psychiatric Disorders

Part Four Disorders of Platelet Number and Function 45. The Clinical Approach to Disorders of Platelet Number and Function 46. Immune Thrombocytopenic Purpura 47. HIV-1-Related Thrombocytopenia 48. Heparin-Induced Thrombocytopenia 49. Drug-Induced Thrombocytopenia 50. Thrombotic Thrombocytopenic Purpura and the Hemolytic-Uremic Syndrome 51. Thrombocytopenia in Pregnancy and the Newborn 52. Alloimmune Thrombocytopenia 53. Inherited Thrombocytopenias 54. Pseudothrombocytopenia 55. Thrombocytosis and Essential Thrombocythemia 56. Inherited Disorders of Platelet Function 57. Acquired Disorders of Platelet Function 58. Cardiopulmonary Bypass

Part Five Pharmacology: Antiplatelet Therapy 59. Aspirin 60. ADP Receptor Antagonists 61. aIIbb3 (GPIIb-IIIa) Antagonists 62. Dipyridamole 63. Cilostazol 64. Experimental Antiplatelet Therapy

Part Six Pharmacology: Therapy to Increase Platelet Numbers and/or Function 65. Platelet Growth Factors 66. Desmopressin (DDAVP) 67. Factor VIIa

Part Seven Platelet Transfusion Medicine 68. Platelet Storage and Transfusion 69. Platelet Substitutes and Novel Methods of Platelet Preservation

Part Eight Gene Therapy for Platelet Disorders 70. Gene Therapy for Platelet Disorders