Drug Resistance in Cancer : Mechanisms and Models (Paperback)

Preface; 1. The biological basis of cancer and the problem of drug resistance; 2. Tumour growth, stem cells and experimental chemotherapy; 3. Molecular aspects of drug resistance; 4. Quantitative descriptions of the origins of drug resistance; 5. Development and exploration of the random mutation model for drug resistance; 6. Extensions of the random mutation model for drug resistance; 7. Clinical predictions of the random mutation model; 8. Directed versus random mutation and the problem of intrinsic resistance; 9. Some final thoughts on the problem of drug resistance; Index.