Familial Breast and Ovarian Cancer : Genetics, Screening and Management (Hardcover)

Part I. Molecular Biology and Natural History: 1. Introduction Patrick Morrison, Shirley Hodgson and Neva Haites; 2. Overview of clinical genetics of breast cancer Neva Haites and Helen Gregory; 3. Cowden syndrome and related disorders Charis Eng; 4. Overview of clinical genetics of ovarian cancer Pierre Chappuis and Will Foulkes; 5. Ovarian cancer as part of HNPCC and other hereditary colon cancer syndromes Hans Vasen and M. A. Nooy; 6. Natural history of hereditary breast cancer Dominique Stoppa-Lyonnet, Will Foulkes and Pierre Chappuis; 7. Pathology of the breast and ovary in mutation carriers Sunil Lakhani and Adrienne M. Flanagan; 8. Risk estimation for familial breast and ovarian cancer Jenny Chang-Claude and Heiko Becher; Part II. Screening: 9. Experience of setting up a cancer genetics service Jonathon Gray; 10. Referral criteria for cancer genetics clinics Diana Eccles; 11. Service aspects of cancer genetic clinics Neva Haites and Shirley Hodgson; 12. Cultural and education aspects influencing development of cancer genetics services in different European countries Shirley Hodgson; 13. Screening, detection and survival patterns of breast and other cancers in high risk families Pal Møller and Michael Steel; 14. Screening for familial ovarian cancer Barnaby Rufford, Usha Menon and Ian Jacobs; Part III. Management: 15. Management of BRCA 1/2 mutation carriers Pierre Chappuis and Will Foulkes; 16. Management of ovarian cancer Dirk Brinkman and Ian Jacobs; 17. Prophylactic mastectomy in mutation carriers Gareth Evans, Fiona Lalloo and Andrew Balidam; 18. Psychosocial aspects of genetic counselling Steven Sutton and Alison Bish; 19. BRCA 1 and 2 testing: uptake and its measurement Lucy Brooks and Gareth Evans; 20. Ethical aspects Patrick Morrison and Michael Steel; 21. Gene therapy of breast and ovarian cancer Richard Kennedy and Patrick Johnston; 22. Future directions Patrick Morrison, Shirley Hodgson and Neva Haites.