From Globular Proteins to Amyloids (Paperback)

1. Description of the fuzzy oil drop model 2. Folding with the active participation of water 3. Information coded in protein structure 4. Glubular or ribbon-like micelle 5. Proteins structured as spherical micelles 6. Local discordance 6. A. The active site in a single-chain enzyme identified as local deficiency of hydrophobicity 6. B. Protein-protein interaction encoded as an exposure of hydrophobic residues on the surface 6. C. Ligand binding cavity coded in form of local defficiency of hydrophobicity 7. Solenoid - amyloid under control 8. Composite structures 9. Permanent chaperons 9. A. Non-amyloid structure of the aß(1-42) polypeptide requiring a permanent chaperone 9. B. Structural properties of aß(1-42) chain fragments in complex with proteins acting as permanent chaperones 10. Amyloids 10. A. Amyloid as a ribbon-like micelle 10. B. Alternative conformations of the aß(1-40) amyloid protein 10. C. Specificity of amino acid sequence and its role in secondary and supersecondary structure generation 11. Anti-amyloid drug design 12. Predicted structure of the transthyretin amyloid