Models of Seizures and Epilepsy (Hardcover, New)

Chapter 1: What Should Be Modeled?

A.: IN VITRO PREPARATIONS

Chapter 2: Single Nerve Cells Acutely Dissociated from Animal and Human Brains for Studies of Epilepsy

Chapter 3: Cell Culture Models for Studying Epilepsy

Chapter 4: An Overview of In Vitro Seizure Models in Acute and Organotypic Slices

Chapter 5: The Use of Brain Slice Cultures for the Study of Epilepsy

Chapter 6: Hippocampal Slices: Designing and Interpreting Studies in Epilepsy Research

Chapter 7: Thalamic, Thalamocortical, and Corticocortical Models of Epilepsy with an Emphasis on Absence Seizures

Chapter 8: Studying Epilepsy in the Human Brain In Vitro

Chapter 9: In Vitro Isolated Guinea Pig Brain

B.: INDUCED SEIZURES IN INTACT ANIMALS

Chapter 10: Pharmacologic Models of Generalized Absence Seizures in Rodents

Chapter 11: Models of Chemically-Induced Acute Seizures

Chapter 12: Electrical Stimulation-Induced Models of Seizures

Chapter 13: Alcohol Withdrawal Seizures

Chapter 14: Alumina Gel Injection Models of Epilepsy in Monkeys

C.: GENETIC MODELS

Chapter 15: Modeling Epilepsy and Seizures in Developing Zebrafish Larvae

Chapter 16: Transgenic and Gene Replacement Models of Epilepsy: Targeting Ion Channel and Neurotransmission Pathways in Mice

Chapter 17: Spontaneous Epileptic Mutations in the Mouse

Chapter 18: Genetic Models of Absence Epilepsy in the Rat

Chapter 19: Models with Spontaneous Seizures and Developmental Disruption of Genetic Etiology

Chapter 20: Mammalian Models of Genetic Epilepsy Characterized by Sensory-Evoked Seizures and Generalized Seizure Susceptibility

Chapter 21: Inherited Epilepsy in Mongolian Gerbils

D.: ACQUIRED FOCAL MODELS

Chapter 22: The Cortical Freeze Lesion Model

Chapter 23: MAM and Other “Lesion? Models of Developmental Epilepsy

Chapter 24: In Utero Irradiation as a Model of Cortical Dysplasia

Chapter 25: Modeling Hypoxia-Induced Seizures and Hypoxic Encephalopathy in the Neonatal Period

Chapter 26: Complex Febrile Seizures-An Experimental Model in Immature Rodents

Chapter 27: Repetitive Seizures in the Immature Brain

Chapter 28: The Kindling Phenomenon

Chapter 29: Kindling Kittens and Cats

Chapter 30: Electrical Kindling in Developing Rats

Chapter 31: Chemical Kindling

Chapter 32: Kindling, Spontaneous Seizures, and the Consequences of Epilepsy: More Than a Model

Chapter 33: Tetanus Toxin Model of Focal Epilepsy

Chapter 34: Kainate-Induced Status Epilepticus: A Chronic Model of Acquired Epilepsy

Chapter 35: The Pilocarpine Model of Seizures

Chapter 36: Status Epilepticus: Electrical Stimulation Models

Chapter 37: Posttraumatic Epilepsy Induced by Lateral Fluid-Percussion Brain Injury in Rats

Chapter 38: Chronic Partial Cortical Isolation

Chapter 39: Head Trauma: Hemorrhage-Iron Deposition

Chapter 40: Stroke

Chapter 41: Models Available for Infection-Induced Seizures

Chapter 42: Brain Tumor and Epilepsy: A New Neurophysiologic and Neuropathologic Ex Vivo In Vitro Model

Chapter 43: An Animal Model of Rasmussen’s Encephalitis

E.: MODELS USED FOR PHARMACOLOGICAL ASSESSMENT

Chapter 44: Therapeutic Assays for the Identification and Characterization of Antiepileptic and Antiepileptogenic Drugs

Chapter 45: Animal Models of Drug-Refractory Epilepsy

F.: TECHNICAL APPROACHES FOR MODEL CHARACTERIZATION

Chapter 46: Monitoring for Seizures in Rodents

Chapter 47: Imaging Approaches in Small Animal Models

Chapter 48: Behavioral Characterization of Seizures in Rats

Chapter 49: Behavioral and Cognitive Testing Procedures in Animal Models of Epilepsy

Chapter 50: Morphologic Approaches to the Characterization of Epilepsy Models

G.: IMPORTANT QUESTIONS

Chapter 51: Animal Model Development Based on the Human Epilepsies: Which Causes and Syndromes Should Be Modeled?

Chapter 52: What Good Are Animal Models?

Index