Complex Enzymes in Microbial Natural Product Biosynthesis, Part B: Polyketides, Aminocoumarins and Carbohydrates: Volume 459 (Hardcover)

Part 1: Polyketides

Overview of polyketide biosynthesis

A) Type I

Structural studies

i) Iterative

Fungal PKSs/FASs
Polyunsaturated fatty acids (PUFAs)
Enediynes

ii) Modular

Macrolides as a paradigm
Macrolides - skipping and stuttering of modules
Trans-AT class
Polyethers
Polyenes
Polyketides in mycobacteria
Docking of subunits
Novel polyketides by genetic engineering
De novo synthesis of pathway genes
Precursor biosynthesis

B) Type II

In vitro analysis and engineering of novel compounds
Bacterial fatty acid biosynthesis

C) Type III

In vitro / in vivo biochemical studies
Structural studies

Part 2: Terpenoids

Enzymology and structural biology of terpenoid biosynthesis

Part 3: Aminocoumarins

Part 4: Carbohydrates

Aminoglycosides
Deoxysugar biosynthesis