Post-Genomic Cardiology - 북프라이스

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· 제목 : Post-Genomic Cardiology (Hardcover, 2, Revised)
· 분류 : 외국도서 > 의학 > 심장학
· ISBN : 9780124045996
· 쪽수 : 944쪽
· 출판일 : 2014-06-04

Dedication
Preface
Section I: Post-Genomic Cardiology
- Chapter 1. Introduction to the Molecular Biology of the Cell
  - Nucleic Acids, Genes, Chromatin, and Chromosomes
  - DNA Transacting Processes: Replication, Transcription, and Repair
  - Genetic Variability Associated with Human Diseases
  - Cell Cycle
  - References
- Chapter 2. Methodologies in the Era of Cardiovascular “Omics?
  - Introduction
  - Genomics Approaches: NGS and GWAS
  - Transcriptomics
  - Proteomics and Interactomics
  - Metabolomics
  - Cardiac Imaging
  - Translational Bioinformatics
  - Conclusions
  - Summary
  - References
- Chapter 3. Post-Genomics Cardiovascular Signaling Pathways
  - Introduction
  - Cardiac Signaling in Physiological Growth
  - Ca²⁺-Mediated Signaling
  - Signaling at the Plasma Membrane
  - Signaling at the Mitochondria
  - Cell-Cycle signaling, cell proliferation, and apoptosis
  - Stress, Survival, and Metabolic Signaling
  - Signaling in Cardiac Development and Aging
  - Conclusion
  - Summary
  - References
Section II: Pediatric Cardiology in the Post-Genomic Era
- Chapter 4. Molecular Determinants of Cardiac Development
  - Introduction
  - Overview of Cardiac Morphogenesis
  - MicroRNAs in Cardiovascular Development
  - Conclusions
  - Summary
  - References
- Chapter 5. Molecular Determinants of Congenital Heart Disease
  - Introduction
  - Etiology of CHD: Interplay of Genetic and Environmental Factors
  - Molecular Mechanisms of CHD
  - Syndromic CHDs Caused by Point Mutations
  - Nonsyndromic CHDs Caused by Point Mutations
  - Non-Syndromic CHD Caused by Impaired Signaling Pathways
  - Nonsyndromic CHD Caused by Point Mutations in Transcription Factors
  - Nonsyndromic CHDs Caused by Point Mutations in Structural Proteins
  - Noncoding RNAs and CHD
  - Conclusions
  - Summary
  - References
Section III: Post-Genomic Assessment of Coronary Artery Disease, Angiogenesis, and Hypertension
- Chapter 6. Molecular Determinants of Atherosclerosis
  - Overview of Atherogenesis
  - Lipoproteins
  - Endothelial Dysfunction
  - Rho Kinases and Statins in Atherosclerosis
  - Tumor Necrosis Factor (TNF) in Atherogenesis
  - Monocytes and Macrophages
  - Antiinflammatory Factors
  - Conclusion
  - Summary
  - References
- Chapter 7. Molecular Genetics of Coronary Artery Disease and Myocardial Infarction
  - Introduction
  - Animal Studies
  - Linkage and Genome-Wide Association Studies in Myocardial Ischemia
  - Candidate Gene Identification Approach
  - Genes and Inflammatory Signaling Pathways Involved in CAD/MI
  - Other Signaling Pathways in CAD/MI
  - Additional Gene LOCI Associated with MI
  - Sex Hormone and MI
  - Gene Profiling in Myocardial Ischemia/Infarct
  - Genetics and Ethnic Differences in Coronary Artery Disease
  - Beyond GWAS
  - MicroRNAs Markers in CAD/MI
  - Conclusions
  - Summary
  - References
- Chapter 8. Cellular and Molecular Aspects of Cardioprotection
  - Introduction
  - Cellular and Molecular Events in IPC
  - IPC and Potassium Channels
  - Signaling Pathways
  - Cell Death
  - Early and Late IPC Pathways
  - IPC and Cell Death
  - Mitochondrial Activity and ATP Levels in IPC
  - Mitochondria and Antioxidants
  - Gene Expression in Early IPC (Signaling Book)
  - Postconditioning and Cardioprotection
  - Remote Conditioning
  - Application in Humans
  - microRNAs in Cardioprotection
  - Conclusions and Future Perspective
  - Summary
  - References
- Chapter 9. Molecular Determinants of Cardiac Neovascularization
  - Introduction
  - Vasculogenesis
  - Angiogenesis
  - Arteriogenesis
  - Molecular Mechanisms of Neovascularization
  - Therapy
  - Conclusions and Future Perspectives
  - Summary
  - References
- Chapter 10. Post-Genomics Appraisal of Systemic and Pulmonary Hypertension
  - Introduction
  - Animal Models of Hypertension
  - Gene Expression and Profiling in Primary Systemic Hypertension
  - Genetics of PPH
  - Conclusions and Future Directions
  - Summary
  - References
Section IV: Post-Genomic Analysis of the Myocardium
- Chapter 11. Post-Genomic Appraisal of Myocarditis
  - Introduction
  - Pathogenesis of Autoimmune Myocarditis
  - Signaling Pathways of Innate and Acquired Immunity
  - Treatment
  - Conclusions
  - Summary
  - References
- Chapter 12. Cardiomyopathies: A Comparative Analysis of Phenotypes and Genotypes
  - Introduction
  - Hypertrophic Cardiomyopathy
  - Genetics of HCM
  - Animal Models of Genetic HCM
  - Dilated Cardiomyopathy
  - Transgenic Models of Dilated Cardiomyopathy
  - Mechanistic Hypotheses of DCM
  - Restrictive Cardiomyopathy
  - Arrhythmogenic Right Ventricular Dysplasia
  - Unclassified Cardiomyopathies
  - Cardiomyopathy and Diabetes Mellitus
  - Genetics in Diabetes
  - Conclusion
  - Summary
  - References
Section V: Heart Failure, Cell Death, and Mitochondria Dynamics
- Chapter 13. Gene Profiling, Energy Metabolism, and Remodeling of the Failing Heart
  - Introduction
  - The Profiling of Gene Expression in Heart Failure
  - Global and Specific Analysis of Gene Expression
  - Epigenetics and HF
  - Histone/Chromatin Modifications; Epigenetic Control of Gene Expression
  - DNA modification/methylation
  - Transcriptional Coactivator p300 and Cardiac Hypertrophy
  - Energy Metabolism Profiling
  - Intracellular Calcium-Cycling Profiling
  - The Genetics of Human HF
  - Bioenergetics and Metabolic Changes in the Failing Heart
  - Mitochondrial DNA Integrity and HF in Transgenic Mice
  - Peroxisome proliferator activated receptor gamma coactivator 1 (PGC1)
  - Peroxisome Proliferator Activated Receptor (PPAR)
  - Mitochondrial Gene Profiling
  - Implication of Metabolic Genes in HF
  - From Cardiac Remodeling to Overt HF
  - Conclusion
  - Summary
  - References
- Chapter 14. Oxidative Stress and Cell Death in Cardiovascular Disease: A Post-Genomic Appraisal
  - Introduction
  - Oxidative Stress
  - Cell Death
  - Conclusions
  - Summary
  - References
- Chapter 15. The Emerging Role of Mitochondrial Dynamics in Cardiovascular Disease
  - Introduction
  - Mechanisms of Mitochondrial Fusion and Fission
  - Physiological Roles of Mitochondrial Dynamics
  - Mitochondrial Dynamics in the Normal and Diseased Heart
  - Conclusions
  - Summary
  - References
Section VI: Molecular and Genetic Analysis of Metabolic Disorders
- Chapter 16. Post-Genomic Analysis of Fatty Acid and Glucose Metabolism in Cardiovascular Disease
  - Introduction
  - Metabolism of Fatty Acids and Glucose in Normal Cardiomyocytes
  - Regulatory Elements of Cardiac Bioenergy Molecules Metabolism
  - Metabolic Dysfunction and Cardiovascular Disease Phenotypes
  - Metabolic Therapies: Current Status and Perspectives
  - Summary
  - References
Section VII: Molecular Genetics of Dysrhythmias
- Chapter 17. Post-Genomic Analysis of Dysrhythmias and Sudden Death
  - Introduction
  - Etiology of Cardiac Dysrhythmias
  - Ventricular Action Potential and Ion Currents
  - Cardiac Ion Channels
  - Properties of Ion Channels
  - Inherited Cardiac Dysrhythmias
  - Acquired Dysrhythmias
  - Mitochondria and Heart Rhythm Disorders
  - Animals Models for Cardiac Dysrhythmias
  - Post-Genomic Approaches to Rhythm Disorders
  - Conclusions and Future Prospects
  - Summary
  - References
Section VIII: Genes, Gender, and Epigenetics
- Chapter 18. Gender and Cardiovascular Disease in the Post-Genomic Era
  - Introduction
  - Sex Steroid Hormones
  - Role of Gonadal Hormones in Cardiac Pathology
  - Animal and In Vitro Studies
  - Studies in Humans
  - Gender-Related Gene Regulation and Cardiovascular Disease
  - Epigenetic and Environmental Factors of Sex-Related Specifics of Cardiovascular Disease
  - Conclusion
  - Summary
  - References
Section IX: Aging and the Cardiovascular System
- Chapter 19. The Aging Heart: A Post-Genomic Appraisal
  - Introduction
  - Telomere Analysis
  - Telomeres and CV Aging
  - Signaling Pathways in the Aging Heart
  - Signaling in the Endothelium in Aging
  - Cellular Damage/Cell Loss, Mitochondria, and CV Aging
  - Reactive Oxidative Species Generation and Aging in the Heart
  - Inflammation and CV Aging
  - Neurohormonal Signaling in CV Aging
  - Prodeath and Prosurvival Signaling Pathways in Aging
  - Signaling Factors in Cell Regeneration of the Aging Heart
  - Genetic Makeup of the Aging Heart
  - Epigenetic and Environmental Factors in Cardiac Aging
  - Gene Transfer in Cardiovascular Tissue
  - Knockout Transgenic Animal Models of Aging
  - Gene Profiling: Transcriptome and Proteomic Analysis
  - Proteomic Analysis
  - DNA Damage and Mutations in Aging
  - Conclusion
  - Summary
  - References
- Chapter 20. Targeted Strategies to Fight Cardiac Aging
  - Introduction
  - Attenuating Cell Death and Remodeling
  - Initiating Prosurvival Pathways
  - Removing “Biological Garbage? in Aging: Targeting Lysosomes, Proteasomes and Other Approaches to Enhance Catabolic Gain
  - Genomic Instability
  - Conclusion
  - Summary
  - References
- Chapter 21. Aging and the Cardiovascular System: The Road Ahead
  - Introduction
  - Genetic Analysis in Aging Research
  - Advances in Human Genotyping and Human Gene Analysis
  - Search for Biomarkers of Human Aging
  - Reversing Aging and/or Dysfunction of Age-Associated Diseases
  - Targeting Specific Organelles in Aging: Mitochondria/Lysosome
  - Diastolic Dysfunction in Aging
  - Pharmacogenomics and Nutrigenomics
  - Conclusions and Future Perspective
  - Summary
  - References
Section X: Genetics, Epigenetics, and New Approaches to Treatment
- Chapter 22. Epigenetics and Cardiovascular Disease
  - Introduction
  - Basic Epigenetic Mechanisms
  - Cardiovascular Epigenetics
  - Conclusions
  - Summary
  - References
- Chapter 23. Gene- and Cell-Based Therapy for Cardiovascular Disease
  - Introduction
  - Gene Therapy
  - Potential Molecular Targets
  - MicroRNA Therapeutics for CVD
  - Cell-Based Therapy
  - Cell Sources
  - Cardiac Progenitor Cells
  - Epicardial Progenitor Cells
  - Strategies for Cell Purification, Delivery, and Engrafting
  - Mechanisms of Heart Regeneration
  - Empowering Human Heart Regeneration
  - Conclusions
  - Summary
  - References
Section XI: Looking to the Future
- Chapter 24. The Path to Personalized Cardiovascular Medicine
  - Introduction
  - Genomic and Epigenomic Analysis
  - Transcriptomics
  - Proteomics and Metabolomics
  - Cardiovascular Pharmacogenetics and Pharmacogenomics
  - Integrating “Omics?: Systems Biology and Network Medicine
  - Conclusions
  - Summary
  - References
Glossary
Index