G Protein Coupled Receptors: Modeling, Activation, Interactions and Virtual Screening Volume 522 (Hardcover)

GPCR Modeling

1. The Protein Local Optimization Program and G-Protein Coupled Receptors: Loop Restoration and Applications to Homology Modeling
2. Modeling Active GPCR Conformations
3. Molecular Modeling of Adenosine Receptors
4. Predicting G Protein-Coupled Receptors Families using Different Physiochemical Properties and Pseudo Amino Acid Composition

Computational Design and Experimental Characterization of GPCR Segment Models

GPCR Interactions with Other Molecules and Cross-Talk

5. G Protein-Coupled Receptor Interaction with Small GTPases
6. Quantification of Receptor Tyrosine Kinase Activation and Transactivation by G Protein Coupled Receptors Using Spatial Intensity Distribution Analysis (SpIDA)
7. NMR Methods for Detection of Small Molecule Binding to RGS4
8. Group II Activators of G-protein Signaling: Monitoring the Interaction of Ga with the G-Protein Regulatory Motif in the Intact Cell
9. Homogeneous Time-Resolved Fluorescence Assay to Probe Folded G Protein-Coupled Receptors
10. cAMP Biosensors Applied in Molecular Pharmacological Studies of G Protein-Coupled Receptors
11. Rhodopsin-Lipid Interactions Studied by NMR

GPCR Bias

12. Biasing the Parathyroid Hormone Receptor: Relating In Vitro Ligand Efficacy to In Vivo Biological Activity

Virtual Screening

13. Application of Monte Carlo-based Receptor-Ensemble Docking to Virtual Screening for GPCR Ligands
14. From Heptahelical Bundle to Hits from the Haystack: Structure-Based Virtual Screening for GPCR Ligands

GPCR Activation

15. Kinetics and Dynamics in the G-Protein Coupled Receptor Signaling Cascade
16. Magic Angle Spinning Nuclear Magnetic Resonance Spectroscopy of G Protein-Coupled Receptors
17. Post-Translation Modification of G Protein-Coupled Receptor in Relationship to Biased Agonism
18. Protein S-Nitrosylation Measurement