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· 분류 : 외국도서 > 과학/수학/생태 > 과학 > 생명과학 > 생화학
· ISBN : 9780128010761
· 쪽수 : 580쪽
· 출판일 : 2016-01-13
목차
Chapter 1: Introduction
Chapter 2: Benefits of Property Assessment and Good Drug-Like Properties
Chapter 3: In Vivo Environments Affect Drug Exposure
Chapter 4: Prediction Rules for Rapid Property Profiling from Structure
Chapter 5: Lipophilicity
Chapter 6: pKa
Chapter 7: Solubility
Chapter 8: Permeability
Chapter 9: Transporters
Chapter 10: Blood-Brain Barrier
Chapter 11: Metabolic Stability
Chapter 12: Plasma Stability
Chapter 13: Solution Stability
Chapter 14: Plasma and Tissue Binding
Chapter 15: Cytochrome P450 Inhibition
Chapter 16: hERG Blocking
Chapter 17: Toxicity
Chapter 18: Integrity and Purity
Chapter 19: Pharmacokinetics
Chapter 20: Lead Properties
Chapter 21: Strategies for Integrating Drug-Like Properties into Drug Discovery
Chapter 22: Methods for Profiling Drug-Like Properties: General Concepts
Chapter 23: Lipophilicity Methods
Chapter 24: pKa Methods
Chapter 25: Solubility Methods
Chapter 26: Permeability Methods
Chapter 27: Transporter Methods
Chapter 28: Blood-Brain Barrier Methods
Chapter 29: Metabolic Stability Methods
Chapter 30: Plasma Stability Methods
Chapter 31: Solution Stability Methods
Chapter 32: CYP Inhibition Methods
Chapter 33: Plasma and Tissue Binding Methods
Chapter 34: hERG Methods
Chapter 35: Toxicity Methods
Chapter 36: Integrity and Purity Methods
Chapter 37: Pharmacokinetic Methods
Chapter 38: Diagnosing and Improving Pharmacokinetic Performance
Chapter 39: Prodrugs
Chapter 40: Effects of Properties on Biological Assays
Chapter 41: Formulation
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