Physiologically Based Pharmacokinetic (Pbpk) Modeling: Methods and Applications in Toxicology and Risk Assessment (Paperback)

1. A history and recent efforts of selected PBPK modeling topics 2. Introduction to Classical Pharmacokinetics 3. Fundamentals of PBPK Modeling 4. PBPK Modeling Software 5. PBPK model: Routes of Chemical Exposures Across Species, Mechanisms of Chemical Absorption 6. PBPK model: Distribution Processes 7. PBPK Model: Metabolism 8. PBPK model: Excretion Via Urine, Feces, And Breath 9. Population PBPK Analysis Methods 10. PBPK Model Calibration, Evaluation, and Performance Assessment 11. Local and Global Sensitivity, Uncertainty And Variability Analyses 12. PBPK modeling In Risk Assessment 13. Tox21, Emerging Methods. High-Throughput Data, And IVIVE