Epigenetics in Cardiovascular Disease: Volume 24 (Paperback)

Preface

Section I: introductory information

1. The ever-growing burden of cardiovascular disease

2. Epigenetics concepts ? an overview

3. From classical signalling pathway to the nucleus

Section II: epigenetics mechanisms in cardiovascular disease

4. DNA methylation in cardiovascular disease development

5. Histone modifications in cardiovascular disease initiation and progression

6. Post transcriptional RNA modifications in cardiovascular disease

7. Regulatory RNAs in cardiovascular disease

8. Regulation of splicing in cardiovascular disease

9. Cardiac Transcriptomic Remodelling in Metabolic Syndrome

10. Sex differences in epigenetics mechanisms of cardiovascular disease

11. Epigenetics of cardiac development and iPS cells

Section III: biomarker value

12. Peripheral Blood DNA and RNA Biomarkers of Cardiovascular Disease in Clinical Practice

13. Epigenetics and physical exercise

14. Long non-coding RNAs and circular RNAs as heart failure biomarkers

15. Artificial intelligence in clinical decision-making for diagnosis of cardiovascular disease

Section IV: therapeutic potential

16. Therapeutic strategies for modulating epigenetic mechanisms in cardiovascular disease

Section V: methodological issues

17. RNA-sequencing and single cell RNA-seq in cardiovascular medicine

18. Good laboratory and experimental practices for microRNA analysis in cardiovascular research

19. Analytical challenges in microRNA biomarker development - Best practices for analyzing microRNAs in cell-free biofluids

20. Concept of biological reference materials for RNA analysis in cardiovascular disease

21. Unbiased bioinformatics analysis of microRNA transcriptomics datasets and network theoretic target prediction

Conclusions and perspectives