AI for Immunology (Hardcover, 1)

Title Page Dedication Page Preface Table of Contents Chapter One:? Understanding Artificial Intelligence (AI) A.????? Introduction B.????? A model for understanding artificial Intelligence C.????? AI Hardware 1.????? Ram (Random access memory) 2.????? Central Processing Unit (CPU) 3.????? Graphic Processing Unit (GPU) 4.????? Servers 5.????? Internet of Things (IoT) D.????? AI Software (Algorithms) 1.????? Application Programming Interface (API)? 2.????? Artificial Neural Network (ANN) a.???? Machine Learning 1)??? Supervised (labeled) data b.???? Deep Learning 1)??? Unsupervised (unlabeled) data 2)??? Reinforcement learning E.????? AI-related computer systems 1.????? Natural Language Processing (NLP) 2.????? Expert Systems 3.????? Big Data Analytics 4.????? Immunoinformatics ? Chapter Two: AI and the bioscience and clinical considerations for immunology A.???? Introduction B.???? Innate (natural) immunity 1.?????? Cellular and humoral (immunochemistry) 2.?????? Review of AI for innate (natural) immunity C.???? Adaptive (acquired) immunity 1.?????? Acute inflammation a.???? Pathophysiology 1)??? Immunohistopathology 2)??? Immunochemistry b.???? Hypersensitivity reactions (Type I to IV) c.???? Clinical considerations in acute inflammation 1)??? Signs and symptoms 2)??? Remove the cause a)???? Hygiene b)??? Anti-infective therapy c)???? Antihistamine/decongestants d)??? Mast cell stabilization 3)?????? Cold therapy 4)?????? Palliative therapy 2.?? Review of AI for adaptive immunity and acute inflammation 3.?? Path to chronic inflammation ? Chapter Three:? AI and chronic inflammation A.???? Introduction B.???? Pathogenesis of chronic inflammation 1.???? Histopathology 2.???? Pharmacodynamics 3.? Review of AI for the pathogenesis of chronic inflammation C.???? Clinical diagnosis and treatment 1.??? Diagnostic strategies 2.??? Treatment (Immunomodulating therapies) 3.??? Review of AI for the clinical diagnosis and treatment for chronic inflammation ? Chapter Four:? AI and autoimmunity A.????? Introduction B.????? Theories of pathogenesis of autoimmune disease 1.???? A prolonged inflammatory process; 2.???? Failure to eliminate an antigen; 3.???? Patient’s genome; 4.???? Environmental factors; 5.???? Increasing release and accumulation of pro-inflammatory cytokines; 6.???? Abnormal immune response to “self” 7.???? Review of AI for the theories of autoimmunity pathogenesis C.??? Clinical manifestations of autoimmune disorders 1.???? Vascular system 2.???? Diffuse organ systems 3.???? Review of AI for the clinical manifestations of autoimmune disorders D.??? Autoimmune disease categories 1.??? Disease descriptions 2.??? Review of AI for autoimmune disease categories E.??? Diagnosis of autoimmune disease 1.???? Physical examination 2.???? Laboratory 3.???? Imaging 4.???? Review of AI in the diagnosis of autoimmune disease F.???? Treatment of autoimmune diseases 1.???? Medical therapies 2.???? Therapeutic procedures a.???? Stem cells transplantation (Regenerative Medicine) b.???? Immunogenetics and Immunogenomics (Molecular biology) 1)?????? CAR-T Cell (Gene replacement) 2)?????? CRISPR-Cas9 (Gene editing) 3.??? Review of AI in the treatment of autoimmune diseases ? Chapter Five: AI and immunology considerations in pandemics and SARS-CoV-2 COVID-19 A.?? Introduction B.?? Background considerations 1.???? Definitions 2.???? History of pandemics a.???? Historical overview b.???? Recent history 3.???? ?Incidence and prevalence of COVID-19 B.?? Pathogenesis, immunologic and immunogenic considerations for SARS-CoV-2 1.???? Mechanisms 2.???? Theories 3.???? Life cycle of SARS-CoV-2 4.???? Review of AI regarding the pathogenesis of SARS-CoV-2? C.?? Clinical considerations for coronavirus (SARS-CoV-2) infection 1.??? Clinical manifestations (signs and symptoms) 2.??? Diagnostic testing a.???? Antigen testing b.???? Molecular genetic testing (PCR test) c.???? Antibody testing 3.???? Treatment and management strategies a.???? General measures 1)?????? Basic preventive steps 2)?????? Mitigation 3)?????? Contact tracing 4)?????? Modeling 5)?????? Herd Immunity and R Naught (R0 or R0) b.???? Therapeutics 1)?????? Monoclonal antibodies 2)?????? Convalescent plasma (serum) 3)?????? Hydroxychloroquine (Plaquenila) combined with azithromycin (Zithromaxa) 4)?????? Remdesivir 5)?????? Dexamethasone (and corticosteroids) 6)?????? RNA screening c.???? Vaccines (Immunization) d.???? CRISPR-Cas13 and RNA screening d.???? Immunoinformatics (computational immunology) 4.???? Review of AI for clinical considerations for coronavirus infections D.??? Epidemiology and public health considerations in COVID-19 1.???? Current epidemiologic considerations 2.???? Review of AI? for epidemiology and public health considerations ? Chapter Six:? Emerging trends and future directions for AI in immunology A.?? The influence of AI and immunology on our personal health and wellness B.?? The influence of AI and immunology on the public health C.?? Current and intermediate considerations of AI applications for immunology D.?? Long range considerations of AI applications for immunology?