Early Vascular Aging (Eva): New Directions in Cardiovascular Protection (Hardcover, 2)

Section I ? Introduction 1. Historical Aspects and Biology of Aging 2. The 5 paradigm shifts in cardiovascular aging research 3. Vascular Aging and Cardiovascular Disease

Section II ? Life course approach and population-based studies 4. Aging Population: Challenges and Opportunities in a Life Course 5. Population-Based Studies: Milestones on the Epidemiological Timeline 6. Lifetime Perspective of Vascular Aging 7. Early Vascular Aging in the Young 8. Vascular Aging and Ethnicity

Section III ? Mechanistic contributions to vascular ageing 9. Cellular and Molecular Determinants of Arterial Aging 10. Early Aging of Endothelial Function and Platelet/Vessel Wall Interactions 11. Age-Induced Endothelial Dysfunction and Intima-Media Thickening 12. Glucose Metabolism, Diabetes, and the Arterial Wall 13. The Cross-Talk Between the Macro- and the Microcirculation 14. Changes in Peripheral Blood Pressure with Normal and Accelerated Aging 15. Changes in Arterial Stiffness with Normal and Accelerated Aging 16. Changes in Central Hemodynamics, Wave Reflection, and Heart-Vessel Coupling with Normal and Accelerated Aging 17. Arterial Stiffness and Blood Pressure Variability 18. Inflammation and other determinants of EVA 19. Psychosocial and economic factors and EVA

Section IV ? Biomarkers, risk prediction and phenotypes of vascular aging 20. Traditional Versus New Models of Risk Prediction 21. Estimated vs measured arterial stiffness 22. Vascular Aging Biomarkers: Methodological Measurement Consensus and Reference values 23. Imaging Biomarkers: Carotid Intima-Media Thickness and Aortic Stiffness as Predictors of Cardiovascular Disease 24. Imaging Biomarkers: Flow Mediated Dilation as Predictor of Cardiovascular Disease 25. Genetic Markers in Prediction of Cardiovascular Disease 26. Arterial Function Evaluation ? Specific vs Combined Biomarker approach 27. Phenotypes of Vascular Aging ? Vascular Chronobiologic asynchrony

Section V ? Vascular aging, organ damage and late-stage disease 28. Early and Late Stages of Chronic Kidney Disease in Relation to Arterial Changes 29. Impact of Arterial Aging on Early and Late Stages of Brain Damage 30. Ventricular-Arterial Coupling and Heart Disease

Section VI ? Translating research into clinical practice in precision cardiovascular medicine: Implications of vascular aging

31. Vascular Aging and Clinical Trials 32. Treatment Aspects 33. Lifestyle Intervention: What Works? 34. Targeting Blood Pressure Lowering and the Sympathetic Nervous System 35. Targeting Central Blood Pressure Through the Macro- and Microcirculation Cross-Talk 36. Cardiovascular Aging in Clinical Guidelines 37. New Drugs Under Development for Cardiovascular Prevention 38. Specific Pathways to prevent Early Vascular Aging 39. Immunization, Vaccines, and Immunomodulation

Section VII ? Global Mapping of Vascular Aging Research 40. Global Mapping of Vascular Aging Research