Radiopharmaceuticals for Positron Emission Tomography, Volume 1 (Hardcover)

Contributors ix

Foreword xvii

Preface xix

Abbreviations xxi

Part 1: Fluorine-18 Labeled Radiopharmaceuticals 1

Chapter 1: Synthesis of [¹⁸F]Fluorodeoxyglucose ([¹⁸F]FDG) 3
Michelle Richards and Peter J. H. Scott

Chapter 2: Synthesis of [¹⁸F]Sodium Fluoride ([¹⁸F]NaF) 15
Brian Hockley and Peter J. H. Scott

Chapter 3: Radiosynthesis of 3'-Deoxy-3'-[¹⁸F]Fluorothymidine ([¹⁸F]FLT) 21
Hartmuth C. Kolb, Henry Padgett, Steve Zigler, Jim Patanella, Fanrong Mu, Umesh Gangadharmath, Vani P. Mocharla, Peter J. H. Scott‡ and Joseph C. Walsh

Chapter 4: Synthesis of [¹⁸F]Fluoroazomycin arabinoside (¹⁸F-FAZA) 31
Brian G. Hockley and Peter J. H. Scott

Chapter 5: Synthesis of [¹⁸F]Fluoromisonidazole (1-(2-Hydroxy-3-[¹⁸F]fluoropropyl)-2-nitroimidazole, [¹⁸F]FMISO) 41
Patrick J. Riss, Valentina Ferrari, Robbie Bielik, Roberto Canales-Candela, Rob Smith, and Franklin I. Aigbirhio

Chapter 6: Synthesis of [¹⁸F]FPPRGD2 51
Shuanglong Liu, Frederick T. Chin, Zhen Cheng and Xiaoyuan Chen

Chapter 7: Synthesis of [¹⁸F]Fluorocholine ([¹⁸F]FCH) 61
David Kryza

Chapter 8: Clinical Manufacturing of [¹⁸F]-16-a-Fluoroestradiol ([¹⁸F]FES) 69
Piyush Kumar and John R. Mercer

Chapter 9: Synthesis of N-Succinimidyl 4-[¹⁸F]Fluorobenzoate ([¹⁸F]SFB) 81
Xia Shao

Chapter 10: synthesis of 4-(2´-Methoxyphenyl)-1-[2'-(N-2''-pyridinyl)-p-[¹⁸F]fluorobenzamido]ethylpiperazine ([¹⁸F]MPPF) 87
Marion Alvarez and Didier Le Bars

Chapter 11: Synthesis of [¹⁸F]Fallypride 95
Laurent Brichard, Valentina Ferrari, Rob Smith, and Franklin I. Aigbirhio

Chapter 12: Synthesis of [¹⁸F]Fluoroethyltyrosine ([¹⁸F]FET) 103
Y. Zhao, A. Alfteimi and M. Zuhayra

Chapter 13: Synthesis of [¹⁸F]Flumazenil ([¹⁸F]FZ) 111
Ralf Schirrmacher, Alexey Kostikov, Gassan Massaweh, Miriam Kovacevic, Carmen Wängler, Alexander Thiel

Chapter 14: Synthesis of 6-[¹⁸F]Fluorodopamine (6-[¹⁸F]FDA) 125
Michael A. Channing, John L. Musachio, and Jozef J. Kusmierz

Chapter 15: Synthesis of 2-([¹⁸F]fluoro)-3-[(2S)-2-Azetidinylmethoxy]Pyridine ([¹⁸F]2FA) 139
Hayden T. Ravert, Daniel P. Holt and Robert F. Dannals

Chapter 16: Synthesis of [¹⁸F]-Substance-P Antagonist-receptor Quantifier ([¹⁸F]SPA-RQ) 155
Sofie Celen, Kim Serdons, Tjibbe de Groot, Terence G. Hamill, and Guy Bormans

Part 2: Carbon-11 Labeled Radiopharmaceuticals 167

Chapter 17: SYNTHESIS OF [¹¹C]-Choline Chloride ([¹¹C]CHL) 169
Brian G. Hockley, Bradford Henderson and Xia Shao

Chapter 18: Synthesis of 2-(4-N-[¹¹C]methylaminophenyl)-6-hydroxybenzothiazole ([¹¹C]6-OH-BTA-1; [¹¹C]PIB) 177
Cécile Philippe, Markus Mitterhauser and Wolfgang Wadsak

Chapter 19: Synthesis of [¹¹C]-Meta-hydroxyephedrine ([¹¹C]MHED) 191
Filippo Lodi, Assunta Carpinelli, Claudio Malizia and Stefano Boschi

Chapter 20: Synthesis of L-[methyl-¹¹C]Methionine ([¹¹C]MET) 199
Amy L. Vavere and Scott E. Snyder

Chapter 21: Synthesis of (+)-α-[¹¹C]-Dihydrotetrabenazine ([¹¹C]DTBZ) 213
Michael R. Kilbourn

Chapter 22: Synthesis of [¹¹C]Flumazenil([¹¹C]FMZ) 221
Roberto Canales-Candela, Patrick J. Riss and Franklin I. Aigbirhio

Chapter 23: Synthesis of [¹¹C]-Hexadecanoic Acid ([¹¹C]Palmitic Acid) 233
Adam C. Runkle, Xia Shao and Peter J. H. Scott

Chapter 24: Synthesis of [O-Methyl-¹¹C]Metomidate ([¹¹C]MTO) 245
István. Boros and Franklin I. Aigbirhio

Chapter 25: Synthesis of [¹¹C]Carfentanil ([¹¹C]CFN) 257
Louis Tluczek and Xia Shao

Chapter 26: Synthesis of [carbonyl-¹¹C]WAY-100635 265
J. D. Andersson, S. Nag, R. Krasikova, V.W. Pike and C. Halldin

Chapter 27: Synthesis of [¹¹C]Raclopride 275
Xia Shao

Chapter 28: Synthesis of 3-Amino-4-[2-(N-Methyl-N-[¹¹C]Methyl-Amino-Methyl)Phenylsulfanyl]-Benzonitrile ([¹¹C]DASB) 285
Daniela Haeusler, Markus Mitterhauser and Wolfgang Wadsak

Chapter 29: Synthesis of [¹¹C]Acetate 297
Filippo Lodi, Claudio Malizia and Stefano Boschi

Chapter 30: Synthesis of N-(2-[¹¹C]Methoxybenzyl)-N-(4-Phenoxypyridin-3-yl)Acetamide ([¹¹C]PBR28) 305
Qi-Huang Zheng, Min Wang and Bruce H. Mock

Part 3: Other Radiopharmaceuticals 313

Chapter 31: Synthesis of [¹³N]Ammonia ([¹³N]NH₃) 315
Peter J. H. Scott

Chapter 32: Synthesis of [⁶⁸Ga]Gallium DOTA-(TYR3)-Octreotide Acetate ([⁶⁸Ga]DOTATOC) 321
Harald Eidherr, Friedrich Girschele, Markus Mitterhauser and Wolfgang Wadsak

Appendix 1: Supplier Information 335

Index 339