Color Atlas of Nerve Biopsy Pathology (Hardcover)

GENERAL CONCEPTS OF PERIPHERAL NEUROPATHY
Classification of Peripheral Neuropathy
Basic Pathological Mechanism
Etiologies of Peripheral Neuropathy
Types of Neuropathies
Symptoms and Signs
Diagnostic Investigations
Nerve Conduction Studies and Needle Electromyography
Laboratory Studies

THE NERVE BIOPSY
Indication for the Nerve Biopsy
Types of Nerve Biopsy
Sural Nerve Biopsy
Sequelae of Nerve Biopsy
Biopsy of Other Nerves

HISTOLOGICAL PROCESSING AND STAINING OF THE BIOPSIED NERVE
Treatment of the Biopsied Nerve
Immediate Care of the Biopsied Nerve
Processing of the Nerve
Paraffin Section Stainings
Frozen Section Stainings
Processing of the Nerve for Semithin and Electron Microscopy Sections
Semithin (0.5 - 1mm) Section Stainings
Nerve Fiber Teasing
Electron Microscope Study

NORMAL NERVE: HISTOLOGY
Age-Related Changes in the Sural Nerve Biopsy

SPECIFIC DIAGNOSTIC PATHOLOGICAL FEATURES OF NERVE BIOPSY
Vasculitis
Amyloid Deposits
Metachromatic Granules
Polyglucosan Body
Onion-Bulb Formation
Inflammatory Cells and Segmental Demyelination
INFLAMMATORY CELLS AND AXONAL DEGENERATION
Noncaseating Granuloma
Necrotizing (Caseating) Granuloma
Giant Axons
Tomacula
Occlusion of Vasa Nervorum
Malignant Cells
IgM Deposits
Segmental Demyelination
Axonal Degeneration

VASCULITIC NEUROPATHY
Vulnerability of the Peripheral Nerve to Vasculitic neuropathy
Clinical, Electromyographic, and Laboratory Features
Diagnostic Sensitivity of Nerve and Muscle Biopsies
Pathology of Vasculitic Neuropathy
Pathogenesis of Vasculitic Neuropathy
Systemic Necrotizing Vasculitides
Vasculitis Associated with Connective Tissue Diseases
Nonsystemic Vasculitic Neuropathy
Vasculitis in Other Diseases
Cases with Vasculitic Neuropathy

INFLAMMATORY DEMYELINATING NEUROPATHY
Pathogenesis of Inflammatory Demyelinating Neuropathies
Guillain-Barre Syndrome (Acute inflammatory Demyelinating Polyneuropathy; AIDP)
Variants of GBS
Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)
Multifocal Motor Neuropathy (MMN)
Multifocal Motor Sensory Demyelinating Neuropathy (MMSDN)
Chronic Sensory Demyelinating Neuropathy (CSDN)
Cases of Inflammatory Demyelinating Neuropathy

IMMUNE-MEDIATED NEUROPATHIES
GM1 Antibody-Positive Neuropathy
Anti-MAG Associated Neuropathy
Neuropathy Associated with Anti-Hu (ANNA 1) Antibody
Neuropathy with Monoclonal Gammopathy
Cases of Immune-Mediated Neuropathy

NEUROPATHIES WITH ABNORMAL DEPOSITS
Amyloid Neuropathy
Metachromatic Leukodystrophy (Sulfatide Lipidosis; Arylsulfatidase Deficiency)
Polyglucosan Body Neuropathy
Fabry's Disease (Alpha-Galactosidase-A Deficiency)
Adrenomyeloneuropathy (AMN)
Cases of Neuropathy with Abnormal Deposit

HEREDITARY NEUROPATHIES
Hereditary Motor and Sensory Neuropathies (HMSN)
Hereditary Sensory Neuropathy
Hereditary Neuropathy to Pressure Palsy (HNPP)
Giant Axonal Neuropathy (GAN)
Friedreich's Ataxia

METABOLIC AND SYSTEMIC NEUROPATHIES
Sarcoid Neuropathy
Sensory Perineuritis
Leprosy
Lymphomatous Neuropathy
Diabetic Neuropathy
Uremic Neuropathy
Alcoholic Neuropathy
Hypothyroid Neuropathy
Vitamin B12 Deficiency Neuropathy
Pyridoxine-Induced Sensory Neuropathy
Polyradiculoneuropathy in Lyme Disease
AIDS Neuropathy

TOXIC NEUROPATHIES
Metal Neuropathies
Drug-Induced Neuropathy
Neuropathy Due to Biological Toxins and Vaccines
Toxic Neuropathy Due to Industrial and Environmental Agents
Epidemic Toxic Inflammatory Neuropathies
Cases of Toxic Neuropathies

INTERPRETATION OF NERVE BIOPSY

INDEX

References are included at the end of each chapter.