Biochemical Modulation of Skin Reactions: Transdermals, Topicals, Cosmetics (Hardcover)

SECTION I: INTRODUCTION AND GENERAL CONSIDERATIONSFundamental Concepts in Transdermal Delivery of Drugs-Agis F. Kydonieus, John J. Wille, and George F. MurphyThe Skin as a Barrier: Structure and Function-Thomas J. Franz and Paul A. LehmanEpidermal Lipid Metabolism and Barrier Function of Stratum Corneum-Philip W. Wertz and Bozena B. MichniakMethods for Testing the Irritation and Sensitization Potential of Drugs and Enhancers-Saqib J. Bashir and Howard I. MaibachQuantitative Structure Analysis Relationships in the Prediction of Skin Sensitization Potential-Saqib J. Bashir and Howard I. MaibachMethods for Testing the Phototoxicity and Photosensitization of Drugs-Norbert J. Neumann, B. Homey, H.W. Vohr, and P. LehmannSECTION II: CELLULAR AND HUMORAL REGULATION AND PATHOGENESISMechanisms of Allergic and Irritant Contact Dermatitis-Paul Wakem and Anthony A. GaspariThe Langerhans Cell: Antigen Processing/Antigen Presentation-Ralf W. Denfeld and Jan C. SimonThe Keratinocyte in Cutaneous Irritation and Sensitization-Alain Coquette, Nancy Berna, Yves Poumay, and Mark R. PittelkowPathogenesis of Allergic Contact Dermatitis: Role of T-Cells-Richard S. KalishThe Keratinocyte In Cutaneous Irritation and Sensitization-Mast Cells Regulate Endothelial Cell Function in Inflammation and Repair-Marcia R. Monteiro and George F. MurphyInterleukin-1 Receptors and Signal Transduction-Charles A. DinarelloProinflammatory Mediators of the Arachidonic Acid Cascade-Kouichi KiaiSECTION III: BIOCHEMICAL MODULATORS AND MODES OF ACTIONModulation of Skin Reactions: A General Overview-Agis F. Kydonieus and John J. WilleGlucocorticoids-Michel Cormier, James Matriano, and Alfred AmkrautIon Channel Modulation of Contact Dermatitis-John J. Wille, Agis F. Kydonieus, and Richard S. KalishMast Cell Degranulating Agents Modulate Skin Immune Responses-John J. Wille, Agis F. Kydonieus, and George F. MurphyModulation of Neurogenic Inflammation by Strontium-Gary S. HahnSkin Tolerability of Iontophoresis Treatment-Bret Berner and Donald R. WilsonThe Effects of Ultraviolet Radiation on the Immune Response-Stephen E. UllrichImmune Tolerance and Its Potential to Control Skin Reactions-Richard S. KalishFuture Prospects and Areas of Promising Research-J. Wayne Streifeiy and Sharmila MasliIndex