Understanding Drug Release and Absorption Mechanisms: A Physical and Mathematical Approach (Hardcover)

Mathematical Modeling Introduction Model Building Model Fitting Models Comparison Conclusions References Gastrointestinal Tract Macro- and Microscopic Anatomy of the Gastrointestinal Tract Intestinal Absorption Human and Animal GI Tract: A Comparison Skin Anatomy Skin Delivery Strategies Animal Model of Skin Delivery References Rheology Introduction Viscosity and Newtonian Fluids Shear-Dependent Viscosity and Non-Newtonian Fluids Shear Flows Not Only Viscosity: Normal Stress Differences and Other Material Functions Extensional Flows and Complex Flows Time-Dependence: Thixotropy and Viscoelasticity Linear Viscoelasticity Rheological Properties and Structural Features Conclusive Considerations on Rheology Applications to Drug Delivery Systems References Mass Transport Introduction Thermodynamic Concepts Kinetics Fick’s Equation Effect of Initial and Boundary Conditions Conclusions References Drug Dissolution and Partitioning Introduction Dissolution Partitioning Dissolution and Partitioning Conclusions References Dissolution of Crystallites: Effects of Size on Solubility Introduction Thermodynamic Concepts Experimental Methods and Limitations Conclusions References Drug Release from Matrix Systems Introduction Matrices Mathematical Modeling Conclusions References Drug Release from Microemulsions Introduction Microemulsions: Structure Microemulsions: Thermodynamics Microemulsions: Experimental Characterization Microemulsions and Drug Release Conclusions References Drug Permeation through Membranes Introduction Synthetic Membranes Biological Membranes Conclusions References Index