Antisense Drug Technology: Principles, Strategies, and Applications, Second Edition (Hardcover, 2)

Introduction
Mechanisms of Antisense Drug Action, an Introduction, S.T. Crooke, T. Vickers, Walt Lima, and H. Wu
The RNase H Mechanism, W. Lima, H. Wu, and S.T. Crooke
Small RNA Silencing Pathways, A. Sigova and P.D. Zamore
Splice Switching Oligonucleotides as Potential Therapeutics, P. Sazani, M.A. Graziewicz, and R. Kole
The Basics of Oligonucleotide-Based Therapeutics
Basic Principles of Antisense Drug Discovery, S.M. Freier and A.T. Watt
The Medicinal Chemistry of Oligonucleotides, E.E. Swayze and B. Bhat
Basic Principles of the Pharmacokinetics of Antisense Oligonucleotide Drugs, A.A. Levin, R.Z. Yu, and R.S. Geary
Routes and Formulations for Delivery of Antisense Oligonucleotides, G.E. Hardee, L.G. Tillman, and R.S. Geary
Liposomal Formulations for Nucleic Acid Delivery, I. MacLachlan
Hybridization-Based Drugs: Basic Properties 2_-O-Methoxyethyl Oligonucleotides
Pharmacological Properties of 2_-O-Methoxyethyl-Modified Oligonucleotides, C.F. Bennett
Pharmacokinetic/Pharmacodynamic Properties of Phosphorothioate 2_-O-(2-Methoxyethyl)-
Modified Antisense Oligonucleotides in Animals and Man, R.S. Geary, R.Z. Yu, A. Siwkowski, and A.A. Levin
Toxicologic Properties of 2_-O-Methoxyethyl Chimeric Antisense Inhibitors in Animals and Man, S.P. Henry, T.W. Kim, K. Kramer-Stickland,T.A. Zanardi, R.A. Fey, and A.A. Levin
An Overview of the Clinical Safety Experience of First- and Second-Generation Antisense Oligonucleotides, T.J. Kwoh
Manufacturing and Analytical Processes for 2_-O-(2-Methoxyethyl)-Modified Oligonucleotides, D.C. Capaldi and A.N. Scozzari
Hybridization-Based Drugs: Basic Properties Duplex RNA Drugs
Utilizing Chemistry to Harness RNA Interference Pathways for Therapeutics: Chemically Modified siRNAs and Antagomirs, M. Manoharan and K.G. Rajeev
Discovery and Development of RNAi Therapeutics, A.R. de Fougerolles and J.M. Maraganore
Other Chemical Classes of Drugs
Optimization of Second-Generation Antisense Drugs: Going Beyond Generation 2.0, B.P. Monia, R.Z. Yu, W. Lima, and A. Siwkowski
Modulating Gene Function with Peptide Nucleic Acids (PNA), P.E. Nielsen
Locked Nucleic Acid, T. Koch and H. Ørum
Morpholinos, P.L. Iversen
Therapeutic Applications
Potential Therapeutic Applications of Antisense Oligonucleotides in Ophthalmology, L.R. Grillone and S.P. Henry
Cardiovascular Therapeutic Applications, R. Crooke, B. Baker, and M. Wedel
Developing Antisense Drugs for Metabolic Diseases: A Novel Therapeutic Approach, S. Bhanot
Inflammatory Diseases, S.A. Gregory and J.G. Karras
Antisense Oligonucleotides for the Treatment of Cancer, B.A. Hadaschik and M.E. Gleave
Targeting Neurological Disorders with Antisense Oligonucleotides, R.A. Smith and T.M. Miller
Mechanisms and Therapeutic Applications of Immune Modulatory Oligodeoxynucleotide and Oligoribonucleotide Ligands for Toll-Like Receptors, J. Vollmer and A.M. Krieg
Aptamer Opportunities and Challenges, C. Wilson
Index