Tumor Suppressor Genes: Volume 2: Regulation, Function, and Medicinal Applications (Hardcover, 2003)

Part I. Understanding the Function and Regulation of Tumor Suppressor Genes Utilizing NMR to Study the Structure of Growth-Inhibitory Proteins Francesca M. Marassi Generation and Application of Phospho-Specific Antibodies for p53 and pRB Yoichi Taya, Kiichiro Nakajima, Kumiko Yoshizawa-Kumagaye, and Katsuyuki Tamai Stability and Ubiquitination of the Tumor Suppressor Protein p53 Lesley J. Jardine and Carl G. Maki Role of Tumor Suppressors in DNA Damage Response Bin-Bing S. Zhou, Michael R. Mattern, and Kum Kum Khanna In Situ Hybridization in Cancer and Normal Tissue Shrihari Kadkol, Jeremy Juang, and Tzyy-choou Wu Genetic Strategies in Saccharomyces cerevisiae to Study Human Tumor Suppressor Genes Takahiko Kobayashi, Ting Wang, Hua Qian, and Rainer K. Brachmann Electrophoretic Mobility Shift Analysis of the DNA Binding of Tumor Suppressor Gene Products Edward C. Thornborrow, Matthew Maurer, and James J. Manfredi Analysis of Gene Promoter Regulation by Tumor Suppressor Genes Kumaravel Somasundaram, Sanjeev Das, Smita Lakhotia, and Narendra Wajapeyee DNA Footprinting M. Stacey Ricci and Wafik S. El-Deiry Identification of DNA-Binding of Tumor Suppressor Genes by Chromatin Immunoprecipitation Timothy K. MacLachlan and Wafik S. El-Deiry Co-immunoprecipitation of Tumor Suppressor Protein-Interacting Proteins Li-Kuo Su Microarray Approaches for Analysis of Tumor Suppressor Gene Function Sally A. Amundson and Albert J. Fornace, Jr. Analysis of Tumor Suppressor Gene-Induced Senescence Judith Campisi Yeast Two-Hybrid Screening as a Means of Deciphering Tumor Suppressor Pathways E. Robert McDonald III and Wafik S. El-Deiry Somatic Cell Knockouts of Tumor Suppressor Genes Ruth Hemmer, Wenyi Wei, Annie Dutriaux, and John M. Sedivy Colony Growth Suppression by Tumor Suppressor Genes Gen Sheng Wu Flow Cytometric Analysis of Cell Cycle Control by Tumor Suppressor Genes David T. Dicker and Wafik S. El-Deiry Analysis of Cyclin-Dependent Kinase Activity Timothy K. MacLachlan and Wafik S. El-Deiry Tumor Suppressor Gene-Inducible Cell Lines Michael Dohn, Susan Nozell, Amy Willis, and Xinbin Chen In Vitro Models of Early Neoplastic Transformation of Human Mammary Epithelial Cells Vimla Band Tumor Suppression Through Angiogenesis Inhibition Andrew M. Arsham and M. Celeste Simon Flow Cytometric Analysis of Tumor Suppressor Gene-Induced Apoptosis David T. Dicker and Wafik S. El-Deiry Functional Analysis of Tumor Suppressor Genes in Mice Stephen N. Jones and Lawrence A. Donehower The Tissue Microenvironment as an Epigenetic Tumor Modifier Meredith Unger and Valerie M. Weaver Analyzing the Function of Tumor Suppressor Genes Using a Drosophila Model Raymond A. Pagliarini, Ana T. Quinones, and Tian Xu Assembling a Tumor Progression Model Mark Redston Conformation-Sensitive Gel Electrophoresis for Detecting BRCA1 Mutations Smita Lakhotia and Kumaravel Somasundaram Part II. Medicinal Applications of Tumor Suppressors Conversion Technology and Cancer Predispositions Nickolas Papadopoulos Discovering Novel Anticancer Drugs: Practical Aspects and Recent Advances Cristina T. Lewis and Patrick M. O'Connor Targets in Apoptosis Signaling: Promise of Selective Anticancer Therapy Ramadevi Nimmanapalli and Kapil Bhalla Tumor Deprivation of Oxygen and Tumor Suppressor Gene Function Zhong Yun and Amato J. Giaccia Hormonal and Differentiation Agents in Cancer Growth Suppression Mikhail V. Blagosklonny Regulation of NF-kB by Oncoproteins and