Bayesian Applications in Pharmaceutical Development (Paperback, 1)

Preface1. Introduction2. Incorporation of Historical Control Data in Analysis of Clinical Trials3. Practical considerations for building priors for confirmatory studies4. The Practice of Prior Elicitation5. Bayesian examples in preclinical in-vivo research6. Planning a model-based Bayesian dose response study7. Novel Designs for Early Phase Drug Combination Trials8. Executing and Reporting Clinical Trial Simulations: Practical Recommendations for Best Practices9. Reporting of Bayesian Analyses in Clinical Research: Some Recommendations10. Handling missing data in clinical trials with Bayesian and Frequentist Approaches11. Bayesian Applications in Pharmaceutical Development12. Simulation for Bayesian Adaptive Designs ? Step-by-Step Guide for Developing the Necessary R Code13. Power Priors for Sample Size Determination in the Process Validation Life-Cycle14. Bayesian Approaches in the Regulation of Medical Products15. Computational tools16. Software for Bayesian Computation - An Overview of Some Currently Available Tools17. Considerations and Bayesian Applications in Pharmaceutical Development for Rare Diseases18. Extrapolation Process in Pediatric Drug Development and Corresponding Bayesian Implementation for Validating Clinical Efficacy19. BM- Appendix: A Brief Guide to Bayesian Model Checking