Extrachromosomal DNA in Cancer : Mechanisms, Biomarkers, and Therapeutic Implications (Hardcover)

Chapter 1 Overview of ecDNA: Discovery and Emerging Significance in Cancer. Chapter 2 Formation and Structure of ecDNA in Cancer Cells. Chapter 3 ecDNA in Oncogene Amplification and Tumor Progression. Chapter 4 Gene Expression and Epigenetic Landscapes of ecDNA in Cancer. Chapter 5 EcDNA: Role in Cancer Drug Resistance. Chapter 6 Imaging, Visualization and characterization of ecDNA in Cancer Cells. Chapter 7 Extrachromosomal DNA in Non-Invasive Cancer Diagnostics. Chapter 8 Extra-chromosomal DNA (ecDNA) as Diagnostic Biomarkers for Cancers. Chapter 9 ecDNA Knowledge for Personalized Medicines. Chapter 10 ecDNA formation: Tumor Immune Escape. Chapter 11 The Role of ecDNA in Tumor Heterogeneity and Evolution. Chapter 12 Role of ecDNA in Cancer Metastasis and Disease Recurrence. Chapter 13 Computational Approaches to Study EcDNA in Cancer Genomics. Chapter 14 ecDNA and Immune Modulation: Progress and Challenges of Cancer Immunotherapy. Chapter 15 Extrachromosomal DNA (ecDNA) and Clinical Implications in Cancer. Chapter 16 Targeting ecDNA: Novel Therapeutic Approach.