Brain Disorders in Critical Illness : Mechanisms, Diagnosis, and Treatment (Hardcover)

Foreword; Introduction; Glossary; Part I. Epidemiology and Outcomes: 1. The epidemiology of critical illness brain dysfunction; 2. Cognitive dysfunction following critical illness; 3. Psychiatric disorders following critical illnesses; 4. Functional status and quality of life after critical illness; 5. Delirium and dementia: unraveling the complex relationship; Part II. Behavioral Neurology in the ICU: 6. Cognitive reserve; 7. Neurology of consciousness impairments; 8. Mechanisms of attention and attentional impairment; 9. Neurology of sleep and sleep disorders; 10. Neural basis of fear and anxiety; Part III. Biological Mechanisms: 11. Experimental models of cognitive dysfunction in infection and critical illness; 12. Neurobiological effects of systemic physiological and metabolic insults; 13. Cerebral ischemia and reperfusion; 14. Brain perfusion and autoregulation in systemic critical illness; 15. Delirium and neurotransmitter dysfunction; 16. Neuromodulatory and neurotoxic effects of sedative agents; 17. Neuroimmunological crosstalk in critical illness; 18. Inflammatory mechanisms in chronic neurodegenerative disease: the impact of microglia priming; 19. The neuroendocrine response to critical illness; 20. Autonomic dysfunction in SIRS and sepsis; 21. Sepsis-induced neuronal dysfunction and death; 22. Neuroimmunomodulation in sepsis; Part IV. Diagnosis of Brain Dysfunction: 23. Clinical neurological assessment of the critically ill patient; 24. Bedside assessment of delirium in critically ill patients; 25. Electroencephalography and evoked potentials in critically ill patients; 26. Neuroimaging of delirium; Part V. Preventative and Therapeutic Interventions: 27. Environmental modification; 28. New paradigms in sedation of the critically ill patient; 29. Pharmacological management of delirium; 30. Pharmacogenomics and cerebral dysfunction; 31. Early physical and occupational therapy; 32. Rehabilitation after critical illness; Part VI. Clinical Encephalopathy Syndromes: 33. Drug-induced encephalopathy; 34. Metabolic encephalopathies: inborn errors of metabolism causing encephalopathies in adults; 35. Encephalopathy associated with alcohol or drug withdrawal; 36. Posterior reversible encephalopathy syndrome (PRES): the essential elements; 37. Hypoxic ischemic encephalopathy; 38. Sepsis-associated encephalopathy; 39. Seizures and status epilepticus in critical illness; 40. Encephalopathy and coma in acute liver failure and chronic liver failure; 41. Neurologic complications of cardiac surgery: stroke, encephalopathy, and cognitive decline; Index.