[eBook Code] Lung Cancer (eBook Code, 4th)

Contributors, viii

Preface, xiii

1 Smoking Prevention and Cessation, 1
Alexander V. Prokhorov and Karen Suchanek Hudmon

2 Lung Cancer Susceptibility and Risk Assessment Models, 25
Xifeng Wu, Xia Pu, and Jie Lin

3 Molecular Profiling, 48
Lauren Averett Byers

4 Somatic Genome Alterations in Human Lung Cancers, 67
Marcin Imielinski, Peter S. Hammerman, Roman Thomas, and Matthew Meyerson

5 Serum Proteomic Biomarkers, 90
Mohamed Hassanein and David P. Carbone

6 Molecular Biology of Lung Preneoplasia, 110
Humam Kadara and Ignacio I. Wistuba

7 Detection and Treatment of Preneoplastic Lesions, 129
Rachel Jen and Stephen Lam

8 Pathology of Adenocarcinoma, 144
William D. Travis

9 Management of Multifocal Bronchioloalveolar Carcinoma (BAC), 158
Howard West

10 Radiology and Lung Cancer Screening, 176
Patricia de Groot and Reginald F. Munden

11 Imaging Lung Cancer, 191
Sonia L. Betancourt Cuellar, Edith M. Marom, and Jeremy J. Erasmus

12 Staging of the Mediastinum, 202
Mauricio Pipkin and Shaf Keshavjee

13 Management of the Solitary Pulmonary Nodule, 214
Min P. Kim

14 Minimally Invasive Resections for Lung Cancer, 224
Shanda H. Blackmon

15 Extended Resections for Lung Cancer, 236
Matthew A. Steliga and David C. Rice

16 Bronchoscopic Interventions for Lung Cancer, 253
Donald R. Lazarus and George A. Eapen

17 Primary Tracheal Tumors, 267
Francesco Sammartino and Paolo Macchiarini

18 Adjuvant Chemotherapy Following Surgery for Lung Cancer, 278
Kathryn A. Gold

19 Neoadjuvant Chemotherapy for Resectable Non-Small Cell Lung Cancer, 290
Christopher G. Azzoli and Katherine M.W. Pisters

20 Image-Guided Radiation Therapy, 309
Kenneth E. Rosenzweig and Sonal Sura

21 Stereotactic Ablative Radiotherapy for Lung Cancer, 320
Puneeth Iyengar and Robert D. Timmerman

22 Proton Therapy, 338
Joe Y. Chang and James D. Cox

23 Combinations of Radiation Therapy and Chemotherapy for Non-small Cell and Small-Cell Lung Carcinoma, 353
Daniel Gomez, Zhongxing Liao, Pierre Saintigny, and Ritsuko U. Komaki

24 Individualized Radiotherapy by Dose Escalation and Altered Fractionation in Non-small Cell Lung Cancer, 379
Heath D. Skinner, Ritsuko U. Komaki, Joe Y. Chang, and James D. Cox

25 Molecular Target Treatment for Personalized Radiotherapy in Lung Cancer, 390
Steven H. Lin and Ritsuko U. Komaki

26 EGFR Tyrosine Kinase Inhibitors and Monoclonal Antibodies: Clinical Trial Review, 406
Kathryn F. Mileham, Edward S. Kim, and William N. William Jr

27 Mechanisms of Resistance to Epidermal Growth Factor Receptor (EGFR) in Non-small Cell Lung Cancer, 421
Erminia Massarelli

28 Predictive Tumor Biomarkers for EGFR Inhibitors, 435
Lucia Kim, Geoffrey Liu, and Ming-Sound Tsao

29 Immunologic Approaches to Lung Cancer Therapy, 454
Jay M. Lee, Steven M. Dubinett, and Sherven Sharma

30 Novel and Emerging Agents in NSCLC, 464
Anne S. Tsao and Jack A. Roth

31 Novel Clinical Trial Designs for Metastatic Lung Cancer, 479
Vassiliki A. Papadimitrakopoulou

32 Novel Statistical Models for NSCLC Clinical Trials, 488
J. Jack Lee and Caleb T. Chu

33 Tumor Microenvironment, Angiogenesis Biology, and Targeted Therapy, 505
John V. Heymach and Tina Cascone

34 Anti-angiogenic Agents in Metastatic NSCLC, 527
Millie Das and Heather Wakelee

35 Targeting ALK Rearrangements, 541
Justin F. Gainor and Alice T. Shaw

36 Non-small Cell Lung Cancers (NSCLC) with Mutations in BRAF, 557
Renata Ferrarotto and George R. Simon

37 Prognostic and Predictive Biomarker Signatures, 564
Johannes R. Kratz and David M. Jablons

38 Brain Metastasis from Lung Cancer, 572
Ritsuko U. Komaki and Amol J. Ghia

Index, 591

Color plate section between pages 146 and 147