[eBook Code] Formulation (eBook Code, 1st)

Preface xi

PART ONE: GENERAL INFORMATION 1

Chapter 1. Introduction 3
André CHEYMOL

1.1. Definition 3

1.2. Historical background 3

1.3. From art to science 8

1.4. Overview of the economical impact of the aforementioned products 14

1.5. Book presentation and structure 15

1.6. Bibliography 16

Chapter 2. Formulation in Major Organic Chemistry Industries 19
André CHEYMOL

2.1. Necessity and concept 19

2.2. Factors affecting different industries 26

2.3. Outlining a methodology 27

2.4. Bibliography 30

PART TWO: CONCEPT AND APPLICATION 31

Chapter 3. Solutions 33
Anne-Marie PENSÉ-LHÉRITIER

3.1. Introduction 33

3.2. Solubilizing in water 35

3.3. Solubilizing in solvents 37

3.4. Processes to help solubilization 43

3.5. Conclusion 48

3.6. Bibliography 49

Chapter 4. Dispersions 53
Gérard HOLTZINGER

4.1. Introduction 53

4.2. Particles and their specificities 54

4.3. Various particle systems and stability issues 62

4.4. Dispersion methods and analysis techniques 89

4.5. Rheology 107

4.6. Bibliography 115

Chapter 5. Formulation of Emulsions 119
Anne-Marie PENSÉ-LHÉRITIER

5.1. General aspects of emulsions 119

5.2. Theoretical considerations on the liquid–liquid interactions 121

5.3. Developing the emulsion 125

5.4. Stabilizing an emulsion 134

5.5. Formulation of emulsions 141

5.6. Conclusion 144

5.7. Bibliography 144

Chapter 6. Suspensions 147
Gérard HOLTZINGER

6.1. Dispersion theory 148

6.2. Formulation of suspensions 155

6.3. Stability agents of suspensions 158

6.4. Specific case of the pharmaceutical realization 164

6.5. Specific case of cosmetics 164

6.6. Using dispersion 167

6.7. Bibliography 183

Chapter 7. Dispersions in High-Viscosity Mediums: Formulating Polymers 185
André CHEYMOL

7.1. Characterization of polymers 185

7.2. Formulation of polymers: general information 198

7.3. Thermal behavior 211

7.4. Heat generation and transmission 216

7.5. Main mixing tools 218

7.6. Conclusion on the polymer formulation rules 227

7.7. Bibliography 227

PART THREE: FORMULATION OF MAJOR PRODUCTS 231

Chapter 8. Dosage Form and Pharmaceutical Development 233
Vincent FAIVRE

8.1. Drugs development 233

8.2. Case study: development of a dosage form for oral administration 246

8.3. Monitoring/checking methods 249

8.4. Bibliography 252

Chapter 9. Formulation of Cosmetic Products 253
Caroline ROUSSEAU

9.1. Introduction 253

9.2. Specifications 254

9.3. Development in the laboratory 256

9.4. Industrial fabrication 265

9.5. Product launch 265

9.6. Regulations 266

9.7. Conclusion 267

Chapter 10. Formulation of Food Products 269
Christine CHÊNÉ

10.1. Specifications 269

10.2. Constraints 271

10.3. Formulation methodology 279

Chapter 11. Formulation of Elastomers 283
André CHEYMOL

11.1. Introduction 283

11.2. Choice of the elastomers 284

11.3. Adjuvants required to obtain crucial functions 290

11.4. Formulation realization: mixture 312

11.5. Conclusion 317

11.6. Bibliography 318

Conclusion 321

List of Authors 323

Index 325