[eBook Code] Dried Blood Spots (eBook Code, 1st)

PREFACE viii

CONTRIBUTORS x

PART I HISTORY, APPLICATIONS, AND HEALTHCARE

1 Overview of the History and Applications of Dried Blood Samples 3
W. Harry Hannon and Bradford L. Therrell, Jr.

2 Dried Blood Spot Cards 16
Brad Davin and W. Harry Hannon

3 Dried Blood Spot Sample Collection, Storage, and Transportation 21
Joanne Mei

4 Dried Blood Spot Specimens for Polymerase Chain Reaction in Molecular Diagnostics and Public Health Surveillance 32
Chunfu Yang

5 Application of Enzyme Immunoassay Methods Using Dried Blood Spot Specimens 40
Mireille B. Kalou

6 Applications of Dried Blood Spots in Newborn and Metabolic Screening 53
Donald H. Chace, Alan R. Spitzer, and Víctor R. De Jesús

7 Dried Blood Spots for Use in HIV-Related Epidemiological Studies in Resource-Limited Settings 76
Sridhar V. Basavaraju and John P. Pitman

8 Use of Dried Blood Spot Samples in HCV-, HBV-, and Influenza-Related Epidemiological Studies 95
Harleen Gakhar and Mark Holodniy

9 Applications of Dried Blood Spots in General Human Health Studies 114
Eleanor Brindle, Kathleen A. O’Connor, and Dean A. Garrett

10 Applications of Dried Blood Spots in Environmental Population Studies 130
Antonia M. Calafat and Kayoko Kato

11 The Use of Dried Blood Spots and Stains in Forensic Science 140
Donald H. Chace and Nicholas T. Lappas

PART II PHARMACEUTICAL APPLICATIONS

12 Pharmaceutical Perspectives of Use of Dried Blood Spots 153
Christopher Evans and Neil Spooner

13 Punching and Extraction Techniques for Dried Blood Spot Sample Analysis 160
Philip Wong and Christopher A. James

14 Considerations in Development and Validation of LC-MS/MS Method for Quantitative Analysis of Small Molecules in Dried Blood Spot Samples 168
Wenkui Li

15 Challenges and Experiences with Dried Blood Spot Technology for Method Development and Validation 179
Chester L. Bowen and Christopher A. Evans

16 Clinical Implications of Dried Blood Spot Assays for Biotherapeutics 188
Matthew E. Szapacs and Jonathan R. Kehler

17 Potential Role for Dried Blood Spot Sampling and Bioanalysis in Preclinical Studies 195
Qin C. Ji and Laura Patrone

18 Clinical and Bioanalytical Evaluation of Dried Blood Spot Sampling for Genotyping and Phenotyping of Cytochrome p450 Enzymes in Healthy Volunteers 202
Theo de Boer, Izaak den Daas, Jaap Wieling, Johan Wemer, and LingSing Chen

19 Application of Dried Blood Spot Sampling in Clinical Pharmacology Trials and Therapeutic Drug Monitoring 216
Kenneth Kulmatycki, Wenkui Li, Xiaoying (Lucy) Xu, and Venkateswar Jarugula

20 Automation in Dried Blood Spot Sample Collection, Processing, and Analysis for Quantitative Bioanalysis in Pharmaceutical Industry 229
Leimin Fan, Katty Wan, Olga Kavetskaia, and Huaiqin Wu

21 Beyond Dried Blood Spots—Application of Dried Matrix Spots 235
Shane R. Needham

PART III NEW TECHNOLOGIES AND EMERGING APPLICATIONS

22 Direct Analysis of Dried Blood Spot Samples 245
Paul Abu-Rabie

23 Paper Spray Ionization for Direct Analysis of Dried Blood Spots 298
Jiangjiang Liu, Nicholas E. Manicke, R. Graham Cooks, and Zheng Ouyang

24 Direct Solvent Extraction and Analysis of Biomarkers in Dried Blood Spots Using a Flow-Through Autosampler 314
David S. Millington, Haoyue Zhang, M. Arthur Moseley, J. Will Thompson, and Peter Smith

25 Development of Biomarker Assays for Clinical Diagnostics Using a Digital Microfluidics Platform 325
David S. Millington, Ramakrishna Sista, Deeksha Bali, Allen E. Eckhardt, and Vamsee Pamula

26 Applications and Chemistry of Cellulose Papers for Dried Blood Spots 332
Jacquelynn Luckwell, Åke Danielsson, Barry Johnson, Sarah Clegg, Mark Green, and Alan Pierce

27 Derivatization Techniques in Dried Blood Spot Analysis 344
Ann-Sofie M.E. Ingels, Nele Sadones, Pieter M.M. De Kesel, Willy E. Lambert, and Christophe P. Stove

INDEX 355