Handbook of Statistics in Clinical Oncology (Paperback, 3 ed)

Choosing a Phase I Design
Barry E. Storer
Dose Finding Designs Based on the Continual Reassessment Method
John O’Quigley and Alexia Iasonos
Pharmacokinetics in Clinical Oncology: Statistical Issues
Gary L. Rosner, Peter Muller, Simon Lunagomez, and Patrick A. Thompson
Statistics of Phase 0 Trials
Larry Rubinstein
CRM Trials for Assessing Toxicity and Efficacy
Sumithra Mandrekar and Dan Sargent
Seamless Phase I/II Trial Design for Assessing Toxicity and Efficacy for Targeted Agents
Antje Hoering, Michael LeBlanc, and John J. Crowley
Overview of Phase II Clinical Trials
Stephanie Green
Designs Based on Toxicity and Response
Gina R. Petroni and Mark R. Conway
Designs Using Time to Event Endpoints/Single Arm versus Randomized Phase II Designs
Catherine M. Tangen and John J. Crowley
Phase II Selection Designs
P.Y. Liu, James (Jim) Moon, and Michael LeBlanc
Phase II with Multiple Subgroups: Designs Incorporating Disease Subtype or Genetic Heterogeneity
Michael LeBlanc, Cathryn Rankin, and John J. Crowley
Phase II/III Designs
Sally Hunsberger
On Use of Covariates in Randomization and Analysis of Clinical Trials
Garnet L. Anderson, Michael LeBlanc, P.Y. Liu, and John J. Crowley
Factorial Designs with Time to Event Endpoints
Stephanie Green
Early Stopping of Clinical Trials
Mary W. Redman
Noninferiority Trials
Kenneth J. Kopecky and Stephanie Green
Phase III Trials for Targeted Agents
Antje Hoering, Michael LeBlanc, and John J. Crowley
Adaptive Trial Designs
Brian P. Hobbs and J. Jack Lee
Design of a Clinical Trial for Testing the Ability of a Continuous Marker to Predict Therapy Benefit
William E. Barlow
Software for Design and Analysis of Clinical Trials
J. Jack Lee and Nan Chen
Cure-Rate Survival Models in Clinical Trials
Megan Othus, John J. Crowley, and Bart Barlogie
Design and Analysis of Quality of Life Data
Andrea B. Troxel and Carol M. Moinpour
Economic Analyses alongside Cancer Clinical Trials
Dean A. Regier and Scott D. Ramsey
Structural and Molecular Imaging in Cancer Therapy Clinical Trials
Brenda Kurland and David A. Mankoff
Prognostic Factor Studies
Martin Schumacher, Norbert Hollander, Guido Schwarzer, Harald Binder, and Willi Sauerbrei
Predictive Modeling of Gene Expression Data
Alexander Hapfelmeier, Waheed Babatunde Yahya, Robert Rosenberg, and Kurt Ulm
Explained Variation and Explained Randomness for Proportional Hazards Models
John O’Quigley and Ronghui Xu
Prognostic Groups by Tree-Based Partitioning and Data Refinement Methods
Michael LeBlanc and John J. Crowley
Risk Calculators
Donna Pauler Ankerst and Yuanyuan Liang
Developing a Score Based upon Gene Expression Profiling and Validation
Pingping Qu, John Shaughnessy, Bart Barlogie, and John J. Crowley
Analysis of DNA Microarrays
Shigeyuki Matsui and Hisashi Noma
Methods for SNP Regression Analysis in Clinical Studies:Selection, Shrinkage, and Logic
Michael LeBlanc, Bryan Goldman, and Charles Kooperberg
Forensic Bioinformatics
Keith A. Baggerly and Kevin R. Coombes
Index