Quantitation and Mass Spectrometric Data of Drugs and Isotopically Labeled Analogs (Hardcover)

2H- Versus ¹³C-Analogs as Internal Standards

Concluding Remarks

References

Isotopically Labeled Analog of the Analyte as Internal Standard for Drug Quantitation ? Chemical Derivatization and Data Collection and Evaluation

Introduction

Chemical Derivatization

Production of Most Favorable Ion-Pairs for Drug Quantitation

Exemplar Studies

Isotopically Labeled Analogs and Chemical Derivatization Groups

Ion Intensity Cross-Contribution Data

Full-Scan Mass Spectra

Selected Ion Monitoring and Calculation of Cross-Contribution Data:

Direct Measurement, Normalized Direct Measurement, Internal Standard Method, Standard Addition Method

Assessing the Accuracy of Empirically Determined Cross-Contribution Data:

Experimentally Observed Concentration, Theoretically Calculated Concentration, Comparing Empirically Derived and Theoretically Calculated Concentrations ? Graphic Presentation, Summary

Compilation of Full-Scan Mass Spectra and Ion Intensity Cross-Contribution Tables:

Derivatization Procedures, Instrumentation, and Analytical Parameters

Collection of Mass Spectrometric Data

Ion Intensity Cross-Contribution Data

Concluding Remarks

References

Part Two. Mass Spectra of Commonly Abused Drugs and Their Isotopically Labelled Analogs in Various Derivatization Forms

Table of Contents for Appendix One

Stimulants

Opioids

Hallucinogens

Depressants/Hypnotics

Antianxiety Agents

Antidepressants

Others

Part Three. Cross-Contributions of Ion Intensity Between Analytes and Their Isotopically Labeled Analogs in Various Derivatization Forms

Table of Contents for Appendix Two

Stimulants

Opioids

Hallucinogens

Depressants/Hypnotics

Antianxiety Agents

Antidepressants

Others

Index