Transdermal and Intradermal Delivery of Therapeutic Agents: Application of Physical Technologies (Hardcover)

Percutaneous Absorption and Enhancement StrategiesStructure and Enzymatic Activity of the SkinPercutaneous AbsorptionPassive Permeation Enhancement StrategiesActive Enhancement Strategies for Percutaneous AbsorptionExperimental Methods and Tools for Transdermal Delivery by Physical Enhancement MethodsConsiderations in Selecting the Skin ModelTransdermal StudiesTape Stripping and MicrodialysisInstrumental Tools Used to Characterize Transdermal TransportMicroporation-Mediated Transdermal Drug DeliverySkin Microporation by MicroneedlesSkin Microporation by Other ApproachesCombination ApproachesApplications of MicroporationIontophoretic Intradermal and Transdermal Drug DeliveryElectrical Properties of SkinPathways of Iontophoretic Drug DeliveryTheoretical Basis of IontophoresisFactors Affecting Iontophoretic DeliverypH Control in Iontophoresis ResearchElectroosmotic FlowReverse IontophoresisTreatment Protocols and Formulations Combined Use of Iontophoresis and Other Enhancement TechniquesApplications of IontophoresisClinical Applications of Iontophoresis for Intradermal DeliverySkin Electroporation and Its ApplicationsElectropermeabilization of the SkinElectroporation EquipmentFactors Affecting Delivery by Electroporation Skin Toxicology of ElectroporationElectroporation for Cancer ChemotherapyDelivery of Drugs by Electroporation Sonophoresis for Intradermal and Transdermal Drug DeliveryFactors Affecting SonophoresisMechanisms of Ultrasound-Mediated Transdermal DeliveryDelivery of Lipophilic DrugsSonophoresis DevicesSkin Irritation and Electrical PropertiesTransdermal Delivery Application of SonophoresisCombination ApproachesHow to Go about Selecting the Optimal Enhancement Method for Transdermal Delivery of a Specific Drug Molecule: Case StudiesIntroductionTechnology Comparison and LimitationsPassive versus Active Patches for Transdermal and Intradermal DeliveryCase StudiesTransdermal Delivery of Peptides and ProteinsStructural Considerations of Polypeptides Relevant to Transdermal DeliveryProtease Inhibitors and Permeation Enhancers for Transdermal Protein DeliveryIontophoretic Delivery of PeptidesTransdermal Delivery of Peptides and Proteins: ExamplesTranscutaneous Immunization via Physical MethodsImmunology of the SkinTranscutaneous Immunization by Passive ApproachesMicroneedle-Based Intradermal InjectionMicroneedle-Mediated VaccinationJet InjectorsDelivery of DNA Vaccines, Genes, and OligonucleotidesCommercial Development of Devices and Products for Transdermal Physical Enhancement TechnologiesWhat Can Be Learned from the Passive Patches on the Market?Safety Issues and Effect of HeatSkin Irritation TestingCommercial Development of Microporation DevicesCommercial Development of Iontophoretic DevicesFormulation ConsiderationsPatch Design and Regulatory IssuesDose and Bioavailability