Enzyme- And Transporter-Based Drug-Drug Interactions: Progress and Future Challenges (Hardcover)

Section I: Determinants of Drug ADME 1. Enzymatic Basis Of Phase I And Phase II Drug Metabolism 2. Transporters: Importance In Drug Absorption, Distribution And Elimination 3. ADME Pharmacogenetics and Its Impact on Drug-Drug Interactions 4. Impact Of Nuclear Receptors, CAR, PXR, FXR, And VDR, And Their Ligands On Enzymes And Transporters 5. Impact of Physiological Determinants: Flow, Binding, Transporters And Enzymes On Organ and Total Body Clearances Section II: Methods For The Study Of Drug-Drug Interactions 6. In Silico Approaches to Predict Drug-Drug Interactions 7. In Vitro Techniques To Study Drug-Drug Interactions Of Drug Metabolism: Cytochrome P450 8. In Vitro Characterization Of Inhibitory Drug-Drug Interactions Involving UDP-Glucuronosyltransferase 9. In Vitro Techniques To Study Transporter-Based Drug-Drug Interactions 10. In Vitro Techniques To Study Drug-Drug Interactions Involving Transport: Caco-2 Model For Study Of P-Glycoprotein And Other Transporters 11. Use Of In Vivo Animal Models To Assess Drug-Drug Interactions12. Extrapolation of In Vitro Metabolic and P-Glycoprotein-mediated Transport Data To In Vivo By Modeling and Simulations 13. Translation Of In Vitro Metabolic Data To Predict In Vivo Drug-Drug Interactions: IVIVE And Modeling And Simulations 14. Absorption Models To Examine Bioavailability And DDI's In Humans 15. Management Of Drug Interactions Of New Drugs In Multicenter Trials Using The Metabolism & Transport Drug Interaction Databaseⓒ 16. Web-Based Database As A Tool To Examine Drug-Drug Interactions Involving Transporters Section III: Impact Of Drug-Drug Interactions 17. Drug Disposition And Drug-Drug Interactions: Importance Of First-Pass Metabolism In Gut And Liver 18. Transporter Based Drug-Drug Interactions And Their Effect On Distribution Volumes 19. Inactivation Of Human Cytochrome P450Enzymes And Drug-Drug Interactions 20. Allosteric Enzyme And Transporter Based Interactions 21. Interplay Of Transporter-Drug Interaction: Complications Of Both Inhibitory And Inductive Events In Drug-Drug Interaction 22. Herbal Supplement-Based Interactions 23. Anticipating And Minimizing Drug Interactions In A Drug Discovery And Development Setting: Industrial Perspective 24. Clinical Studies Of Drug-Drug Interactions: Design And Interpretation 25. Toxicological Consequences Of Drug Drug Interactions Section IV: Regulatory Aspects And Future Developments Involving DDI 26. Complex Drug Interactions: Significance And Evaluation 27. DDI: Labeling And Marketing Perspectives 28. Drug-Drug Interactions: What Have We Learnt And Where Are We Going?