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· 분류 : 외국도서 > 의학 > 심장학
· ISBN : 9781455728565
· 쪽수 : 1365쪽
· 출판일 : 2013-10-25
목차
Part I. Structural and Molecular Bases of Ion Channel Function 1 Voltage-Gated Sodium Channels and Electrical Excitablility of the Heart 2 Calcium Channels in the Heart 3 Voltage-Regulated Potassium Channels 4 Structural and Molecular Bases of Inward Rectifier Potassium Channel Function 5 Mammalian Calcium Pumps in Health and Disease 6 Structural and Molecular Bases of Sarcoplasmic Reticulum Ion Channel Function 7 Structural and Molecular Bases of Mitochondrial Ion Channel Function 8 Molecular Organization, Gating, and Function of Gap Junction Channels Part II. Biophysics of Cardiac Ion Channel Function 9 Biophysics of Normal and Abnormal Cardiac Sodium Channel Function 10 Regulation of Cardiac Calcium Channels 11 KCNQ1/KCNE1 Macromolecular Signaling Complex: Channel Microdomains and Human Disease 12 Structural Determinants and biophysical properties of hERG channel gating 13 Molecular regulation of cardiac inward rectifier potassium channels by pharmacologic agents 14 Cardiac Stretch-Activated Channels and Mechano-Electric Coupling 15 Biophysical Properties of Gap Junctions 16 Excitation-Contraction CouplingPart III. Intermolecular Interactions and Cardiomyocyte Electrical Function 17 Ion Channel Trafficking in the Heart 18 Macromolecular Complexes and Regulation of the Sodium Channel Na v 1.5 19 Calmodulin and CaMKII as Ca2+ switches for cardiac ion channels 20 Macromolecular Complexes and Cardiac Potassium Channels 21 Reciprocity of Cardiac Sodium and Potassium channels in the control of Excitability and Arrhythmias 22 The Intercalated Disc: A Molecular Network that Integrates Electrical Coupling, Intercellular Adhesion, and Cell Excitability 23 Scaffolding Proteins and Ion Channel Diseases 24 Epigenetics in Cardiac Rhythm Diseases Part IV. Cell Biology of Cardiac Impulse Initiation and Propagation 25 Cardiac Impulse is Initiated by a Coupled System of Membrane Ion Channels and Ca 2+ Cycling Proteins 26 Biological Pacing 27 Intercellular Communication and Impulse Propagation 28 Mechanisms of Atrioventricular Nodal Excitability and Propagation 29 Cell Biology of the Specialized Cardiac Conduction System 30 Cardiac Fibroblasts and Arrhythmogenesis Part V. Models of Cardiac Excitation 31 Ionic Mechanisms of Atrial Action Potentials 32 Models of the Ventricular Action Potential in Health and Disease 33 Calcium Signaling in a Cardiomyocyte Models with Realistic Geometries 34 Theory of Rotors and Arrhythmias 35 Supraventricular Arrhythmias in a Realistic 3D model of the Human Atria 36 Cardiac Electromechanical Models Part VI. Neural Control of Cardiac Electrical Activity 37 Ca v 1.2 and ß-Adrenergic regulation of cardiac function 38 cholinergic and constitutive regulation of atrial potassium channel 39 Pulomnary vein ganglia and the neural regulation of the heart rate 40 Neural activity and atrial tachyarrhythmias 41 Sympathetic Innervation, Denervation, and cardiac arrhythmias Part VII. Arrhythmia Mechanisms 42 Dominant Frequency and the Mechanisms of Initiation and Maintenance of Atrial fibrillation 43 Rotors in Human Atrial Fibrillation 44 atrial ischemia and fibrillation 45 The Molecular pathophysiology of atrial fibrillation 46 Myofibroblasts, Cytokines and Persistent Atrial Fibrillation 47 Role of The Autonomic Nervous System In Atrial Fibrillation 48 Mechanisms of ventricular tachycardia and fibrillation Part VIII. Molecular Genetics and Pharmacogenomics 49 Genetics of Atrial Fibrillation 50 Mechanisms in Heritable Sodium Channel Diseases 51 Inheritable Potassium Channel Disease 52 Genetics and Cellular Mechanisms of the J Wave Syndromes 53 Inheritable Phenotypes Associated with Altered Intracellular Calcium Regulation Part IX. Pharmacologic, Genetic and Cell Therapy of Ion Channel Dysfunction 54 Pharmacologic Bases of Antiarrhythmic Therapy 55 Pharmacogenomics of Cardiac Arrhythmias 56 Optogenetic Control of Heart Muscle 57 Cell Therapy and Regeneartive Elec














