Mhc Class I Antigens in Malignant Cells: Immune Escape and Response to Immunotherapy (Paperback, 2013)

Chapter 1: INTRODUCTION-The role of MHC antigens in T- and NK-cell-mediated immunity -Mechanisms of cancer immune escape Chapter 2: TUMOR MHC CLASS I EXPRESSION -Improved detection of HLA class I alterations due to the development of novel techniques and new more specific monoclonal antibodies -Difficulties in defining MHC type of alterations in tumor tissue Chapter 3: MHC CLASS I AND TUMOR PROGRESSION-HLA class I and cancer progression in humans -MHC class I and metastatic progression in mouse models -MHC-I and local tumor growth -MHC-I expression in primary tumors and metastatic lesions Chapter 4: MECHANISMS OF ALTERATIONS OF HLA CLASS I EXPRESSION -Reversible -Irreversible Chapter 5: ROLE OF MHC CLASS I ALTERED EXPRESSION IN RESISTANCE TO IMMUNOTHERAPY -HLA and resistance to immunotherapy in melanoma and bladder cancer -MHC-I expression in spontaneous experimental metastases and response to immunotherapy -Application of different types of cancer immunotherapy in: MHC-I positive tumors and metastases Primary tumors and metastases with intermediate level of MHC-I expression Comparison with chemotherapy -Different approaches to recover normal HLA class I expression to increase tumor immunogenicity