Nonsense-mediated Mrna Decay (Paperback)

Preface Section I: Saccharomyces cerevisiae 1. Features of Nonsense-Mediated mRNA Decay in Saccharomyces cerevisiae 2. All Termination Events Are Not Equal: Premature Termination in Yeast Is Aberrant and Triggers NMD 3. Endogenous Substrates of the Yeast NMD Pathway 4. NMD in Mammalian Cells: A History 5. Human Upf Proteins in NMD 6. NMD and the Immune System 7. Role of SMG-1-Mediated Phosphorylation of Upfl in NMD Section II: Mammals 8. Physiologie Substrates and Functions for Mammalian NMD 9. NMD and Human Disease 10. Therapies of Nonsense-Associated Diseases Section III: Caenorhabditis elegans 11. NMD in Caenorhabditis elegans Section IV: Drosophila melanogaster 12. NMD in Drosophila: A Snapshot into the Evolution of a Conserved mRNA Surveillance Pathway 13. NMD in Plants 14. Regulation of Gene Expression by Coupling of Alternative Splicing and N M D 15. NMD and the Evolution of Eukaryotic Gene Structure 16. The SMG-1 Kinase: At the Crossroads of mRNA Surveillance and Stress Response Pathways 17. Staufen 1-Mediated mRNA Decay: A Upf1-Dependent Pathway Section V: Plants 18. Upfl Regulates Mammalian Histone mRNA Decay 19. S. cerevistae Esti///, sapiens SMG6 Protein Family Members Function in Telomere Metabolism 20. Nonsense-Associated Altered Splicing.