THE CELL A MOLECULAR APPROACH 7E PI (Hardcover)

Part I. Fundamentals and Foundations.- 1. An Overview of Cells and Cell Research.- New discussion of super-resolution light microscopy.- New Key Experiment: HeLa cells.- 2. Molecules and Membranes.- Reorganized to include discussion of enzymes and catalysis.- 3. Bioenergetics and Metabolism.- Reorganized to include discussion of the mechanisms of oxidative phosphorylation and photosynthesis.- 4. Fundamentals of Molecular Biology.- Additional discussion of real-time PCR.- New discussion of the CRISPR/Cas system.- 5. Genomics, Proteomics, and Systems Biology.- New chapter focusing on genomics, proteomics, and systems biology.- Added discussion of next-generation sequencing.- New section on Synthetic Biology.- New Molecular Medicine: Malaria and Synthetic Biology.- Part II. The Flow of Genetic Information.- 6. Genes and Genomes.- Updated discussion of noncoding RNAs.- New Key Experiment: The ENCODE Project.- 7. Replication, Maintenance, and Rearrangements of Genomic DNA.- New discussion of DNA rearrangement and yeast mating types.- 8. RNA Synthesis and Processing.- Discussion of the role of ?-ketoglutarate in catabolite repression.- Updated information on insulators and transcriptional domains.- New section on Chromatin and Epigenetics.- Updated discussion of lncRNAs.- 9. Protein Synthesis, Processing, and Regulation.- New discussion of prions.- Updated information on protein modification by ubiquitin and SUMO.- New Molecular Medicine: Alzheimer's Disease.- Part III. Cell Structure and Function.- 10. The Nucleus.- New information on the organization of chromosome domains within the nucleus.- Updated discussion of nuclear bodies.- 11. Protein Sorting and Transport: The Endoplasmic Reticulum, Golgi Apparatus, and Lysosomes.- Updated discussion of the insertion of membrane proteins in the ER.- New information on protein trafficking through the Golgi.- Updated discussion of vesicle docking and fusion.- 12. Mitochondria, Chloroplasts, and Peroxisomes.- Updated discussion of chloroplast genomes and protein import.- New information on peroxisome biogenesis.- New Molecular Medicine: Peroxisome Biogenesis Disorders.- 13. The Cytoskeleton and Cell Movement.- Updated discussion of actin filament remodeling at the leading edge.- 14. The Plasma Membrane.- Updated discussion of plasma membrane domains, lipid rafts and caveolae.- New information on clathrin-independent endocytosis.- Updated Molecular Medicine to include new information on drug treatment of cystic fibrosis.- 15. Cell Walls, the Extracellular Matrix, and Cell Interactions.- New discussion of the role of bacterial cytoskeletal proteins in cell wall synthesis and cell shape.- Updated information on a-catenin linkage to actin.- Part IV. Cell Regulation.- 16. Cell Signaling.- Chapter reorganized to focus on integrated signaling pathways.- 17. The Cell Cycle.- Expanded discussion of the initiation of DNA synthesis and role of APC/C.- New information on the spindle assembly checkpoint.- 18. Cell Death and Cell Renewal.- Expanded discussion of programmed cell death by autophagy and necroptosis.- New information on stem cell niches.- 19. Cancer.- Updated discussion of cancer genomics.- New information on targeted therapies.