Breast Cancer: Innovations in Research and Management (Hardcover, 2017)

Part I An Integrated view of Breast Cancer Biology.- Fundamental pathways in breast cancer 1: signaling from the membrane.- Fundamental pathways in breast cancer 2: maintenance of genomic stability.-Fundamental pathways in breast cancer 3: estrogen biology.- Fundamental pathways in breast cancer 4: maintenance of epigenomic stability and the role of stem cells.- Breast cancer microenvironment and the metastatic process.- Mouse models of breast cancer.- Human mammary tumor virus proteins in human breast cancer cells.- Part II Epidemiology, Genetics and Prevention.- Epidemiology, life style and environment.- Genetic predisposition.- Chemoprevention.- Surgical prevention.- Part III Pathology: Standard and Molecular Diagnostics.- Premalignant lesions.- Prognostic and predictive role of genetic signatures.- Adding molecular information to immunohistochemistry.- Special types of breast cancer and nonepithelial tumors.- Pathology after neoadjuvant treatments.- Breast cancer genomics.- Pathology report 2015.- Part IV Imaging.- Radiological screening of breast cancer. Evolution.- Innovation of radiological means for breast cancer.- Nuclear medicine in the clinical management (ROLL, SNB and PET).- One-step systemic staging for patients with breast cancer.- Imaging after breast surgery.- Integrated breast biopsy for best radiological diagnosis of breast cancer.- Part V Oncological Surgery.- Conservative surgery.- Conservative mastectomies.- Surgical treatment of reappearance of breast cancer.- Management of the axilla.- Management of intraepithelial disease.- Surgery after neoadjuvant therapies.- Surgery of primary tumor in stage IV breast cancers.- Local therapy for breast cancer in malignant lymphoma survivors.- Surgery of metastases.- Part VI Plastic and Reconstructive Surgery.- Oncoplastic surgery.- Delayed breast reconstruction.- Immediate breast reconstruction direct-to-implant.- Breast reconstruction with tissue expanders and definitive implant replacement.- Breast reconstruction with pedicled flaps.- Breast reconstruction with free flaps.- Contralateral breast management.- Fat grafting in breast reconstruction.- Breast reconstruction with biological and nonbiological meshes.- How to manage complications in breast reconstruction.- Part VII Medical Oncology.- Adjuvant systemic therapies by subtypes: guidelines.- Primary systemic therapies: guidelines.- Treatment of advanced disease: guidelines.- Endocrine therapies in the adjuvant and advanced disease settings.- Chemotherapy regimens in the adjuvant and advanced disease settings.- Anti-HER2 therapies in the adjuvant and advanced disease settings.- Systemic therapy with bisphosphonates and anti-RANK-L agents.- Systemic treatment for specific medical situations.- Part VIII Radiotherapy.- Conceptual basis and principles of radiation oncology.- Whole breast radiation following breast-conserving surgery in invasive cancer.- Whole breast radiation following breast-conserving surgery in noninvasive cancer.- Post-mastectomy radiotherapy.- Integration of radiotherapy with systemic therapies.- Partial breast irradiation.- Intraoperative radiotherapy ELIOT.- Radiotherapy for metastatic lesions.- Part IX Special Conditions Requiring Multidisciplinary Approaches.- Emergencies in breast cancer.- Breast cancer during pregnancy.- Fertility issues in patients with newly diagnosed breast cancer.- Sexual functions and breast cancer.- Male breast cancer.- Inflammatory breast cancer.- Treatment of CNS involvement.- Treatment of skeletal disease.- Follow-up of patients with breast cancer.- Part X Investigating New Drugs and Immunological Agents in Breast Cancer.- Targeting immune-checkpoint.- Targeting PIK3CA/AKT/mTOR.- Targeting genome instability and DNA repair.- Targeting CDK4/6 pathway.- Targeting FGFR pathway.- Integrating next generation sequencing data in trial design.- Part XI Investigational and Miscellaneous Approaches.- Lifestyle and breast cancer.- Psychological support.- HIFU and radiofrequ