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· 제목 : Mechanisms of Gene Regulation: How Science Works (Paperback)
· 분류 : 외국도서 > 의학 > 연구
· ISBN : 9783030523206
· 쪽수 : 149쪽
· 출판일 : 2020-10-30
· 분류 : 외국도서 > 의학 > 연구
· ISBN : 9783030523206
· 쪽수 : 149쪽
· 출판일 : 2020-10-30
목차
1 Genes and chromatin
1.1 Central dogma of molecular biology
1.2 Impact of chromatin structure
1.3 Epigenetics enables gene expression
1.4 Gene regulation in the context of nuclear architecture
2 Basal transcriptional machinery
2.1 Core promoter
2.2 TATA box and other core promoter elements
2.3 Genome-wide core promoter identification
2.4 TFIID and Mediator as paradigms of multi-protein complexes
3 Transcription factors and signal transduction
3.1 Site-specific transcription factors and their domains3.2 Classification of transcription factors
3.3. Activation of transcription factors
3.4 Programing cellular differentiation by transcription factors
3.5 Inflammatory signaling via NF-?B
3.6 Sensing cellular stress via p534 A key transcription factor family: Nuclear receptors
4.1 The nuclear receptor superfamily
4.2 Molecular interactions of nuclear receptors
4.3 Physiological role of nuclear receptors
5 Genome-wide principles of gene regulation
5.1 Next-generation sequencing
5.2 Gene regulation in the context of Big Biology
5.3 Exploring genome-wide transcription factor binding
5.4 Integrating epigenome-wide datasets
6 Chromatin modifiers
6.1 Cytosines and their methylation
6.2 Histone modifications
6.3 Gene regulation via chromatin modifiers
6.4 Sensing energy metabolism via chromatin modifiers
7 Epigenetics
7.1 Epigenetics and chromatin
7.2 Genome-wide understanding of epigenetics7.3 CTCF and genetic imprinting
7.4 Epigenetics in health and disease
8 Chromatin remodeling and organization
8.1 Nucleosome positioning at promoters
8.2 Chromatin remodeling
8.3 Transcriptional dynamics in the presence of chromatin
8.4 Organization of the nucleus
9 Regulatory impact of non-coding RNA
9.1 Non-coding RNAs
9.2 miRNAs and their regulatory potential
9.3 Long ncRNAs
9.4 Enhancer RNAs
