Advances in Host-Directed Therapies Against Tuberculosis (Hardcover)

· 제목 : Advances in Host-Directed Therapies Against Tuberculosis (Hardcover) 
· 분류 : 외국도서 > 의학 > 면역학
· ISBN : 9783030569044
· 쪽수 : 332쪽
· 출판일 : 2020-12-04

Section 1: Introduction

Chapter 1:           Introduction: An overview of host-directed therapies for tuberculosis

Daniel Frank, Robert Mahon

 

Section 2: Targeting immunometabolism

Chapter 2:           Sirtuin deacetylases: Linking Mycobacterial infection and host metabolism

Lorissa Smulan, Hardy Kornfeld, and Amit Singhal

Chapter 3:           The mammalian target of rapamycin complex 1 (mTORC1): an ally of M. tuberculosis in host cells

Natalie Bruiners, Valentina Guerrini, Maria Laura Gennaro

Chapter 4:           HIF-1α as a potential therapeutic target for tuberculosis treatment

                                Qingkui Jiang, Maria Laura Gennaro, Lanbo Shi

Chapter 5:           Nuclear receptors in host-directed therapies against tuberculosis

                                Eun-Kyeong Jo

 

Section 3: Enhancing anti-mycobacterial mechanisms

Chapter 6:           Autophagy as a target for host-directed therapy against tuberculosis

                                Surbhi Verma, Raman Deep Sharma and Dhiraj Kumar

Chapter 7:           Metformin: a leading HDT candidate for TB

                                Amit Singhal and Hardy Kornfeld              

Chapter 8:           Statins as host-directed therapy for tuberculosis

Noton K. Dutta, Petros C. Karakousis

Chapter 9:           Antimycobacterial attributes of mitochondria: An insight into host defense mechanisms

Rikesh K Dubey, Apoorva Narain

 

Section 4: Targeting immune cells

Chapter 10:        Conventional and unconventional lymphocytes in immunity against Mycobacterium tuberculosis

                                Paula Ruibal, Tom H.M. Ottenhoff, Simone A. Joosten

Chapter 11:        Targeting inhibitory cells such as Tregs and MDSCs in the tuberculous granuloma

Sadiya Parveen, John R. Murphy, and William R. Bishai

Chapter 12:        Targeting suppressor T cells

                                Leanie Kleynhans, Gerhard Walzl

Chapter 13:        Neutrophil-mediated mechanisms as targets for host-directed therapies against tuberculosis

                                Tobias Dallenga, Ulrich E. Schaible

Chapter 14:         Type I interferon and interleukin-1 driven inflammatory pathways as targets for HDT in tuberculosis

Katrin D. Mayer-Barber, Christopher M. Sassetti

Chapter 15:        Mucosal-associated invariant and Vγ9Vδ2 T cells

Charles K. Vorkas, Michael S. Glickman

Chapter 16:        Airway epithelial cells

Angelica M. Olmo-Fontanez, Jordi B. Torrelles

 

Section 5: Preclinical models for assessing HDTs

Chapter 17:        In vitro models of human granuloma formation to analyze host-directed therapies

Liku B. Tezera, Michaela T. Reichmann, Basim Al Shammari, Paul T. Elkington

Chapter 18:        C3HeB/FeJ as a key mouse strain for testing host-directed therapies against tuberculosis

Pere-Joan Cardona, Cristina Vilaplana

Chapter 19:        The Rabbit Model for Assessing Host-Directed Therapies for Tuberculosis

 Selvakumar Subbian, Gilla Kaplan

 

Section 6: Clinical trials of HDTs and special considerations for study endpoints

Chapter 20:        Clinical trials of TB-HDT candidates

Robert S. Wallis

Chapter 21:        Outcomes for clinical trials of host-directed therapies for tuberculosis

Akshay N. Gupte, Sara C. Auld, William N. Checkley, Gregory P. Bisson

Chapter 22:        Pharmacological considerations for clinical trials of host-directed therapies for tuberculosis      

Elisa H. Ignatius, Kelly E. Dooley