Trials for Cerebellar Ataxias: From Cellular Models to Human Therapies (Paperback, 2023)

Part I:?Basic Science of Cerebellum and Ataxias.-?Functional anatomy of the cerebellum.-?Cerebellar physiology.-?Cerebellar biochemistry/pharmacology.-?Genetics of dominant ataxias.-?Autosomal and X-linked degenerative ataxias: from genetics to promising therapeutics.-?Seeking therapies for Spinocerebellar Ataxia: from gene silencing to systems-based approaches.-?Ion Channel Genes and Ataxia.- Part II:?Biomarkers and tools of trials.-?How to Design a Therapeutic Trial in SCAs.-?Therapy development for spinocerebellar ataxia: Rating Scales and Biomarkers.-?Clinical rating scales for ataxia.-?Scale for Ocular motor Disorders in Ataxia (SODA): Procedures and Basic Understanding.-?Cerebellar learning in the prism adaptation task.-?Blood and CSF biomarkers in autosomal dominant cerebellar ataxias.- Part III:?Autosomal Dominant Cerebellar Ataxias.-?Riluzole in progressive cerebellar ataxias.-?ASOs against ATXN2 in preclinical and phase 1 trials.-?Antisense oligonucleotide therapy against SCA3.-?Spinocerebellar ataxia type 7: From mechanistic pathways to therapeutic opportunities.-?Experimental neurotransplantation for cerebellar ataxias.-?Development of mesenchymal stem cells therapy for the treatment of polyglutamine SCA: from bench to bedside.-?Cerebello-Spinal tDCS as Rehabilitative Intervention in Neurodegenerative Ataxia.-?Cerebellar Transcranial Magnetic Stimulation in Cerebellar Ataxias.-?Physical therapy in Cerebellar Ataxia.- Part IV:?Autosomal Recessive Cerebellar Ataxias.-?Recent advances on therapeutic approaches for Friedreich's Ataxia.-?Therapeutic use of interferon gamma in Friedreich ataxia.-?Metabolic treatments of cerebellar ataxia.-?Clinical Trials in Fragile X-Associated Tremor/Ataxia Syndrome.- Part V:?Sporadic Ataxias.-?Therapeutic strategies inimmune-mediated cerebellar ataxias.-?Coenzyme Q10 in MSA.-?State of the Art and History of Therapeutics in Ataxias.