Bioinformatics for Evolutionary Biologists: A Problems Approach (Hardcover, 2017)

Part I UNIX.- 1 Getting Started.- 2 Files.- 3 Scripts. Part II Optimal Alignment.- 4 Sequence Evolution.-and Alignment.- 5 Amino Acid Substitution Matrices.- 6 Protein Evolution.- 7 The Number of Possible Alignments.- 8 Dot Plots.- 9 From Dot Plot to Alignment.- 10 Optimal Global Alignment.- 11 Age of the Adh/Adh-dup Gene Duplication in Drosophila.- 12 Optimal and Simplified Local Alignment.- Part III Exact Matching.- Classical Methods.- 14 Suffix Trees.- 16 Text Compression.- Part IV Fast Alignment.-17 Shotgun Sequencing.- 18 Fast Global Alignment.- 19 Fast Local Alignment.- 20 Statistics of Local Alignments.- 21 Clustering of the M. genitalium Proteome.- 22 Position-Dependent Amino Acid Score Matrix: PSI-BLAST.- 23 Optimal Multiple Sequence Alignment.- 24 Heuristic Multiple Sequence Alignment.- Part V Phylogeny.- 26 Rooted Phylogeny.- 27 Unrooted Phylogeny.- Part VI Coalescent.-28 Ancestors.- 29 The Wright-Fisher Model.- 30 The Coalescent.- 31 The Coalescent with Recombinati on.- Part VII Answers.- References