A Clinician's Guide to Sperm DNA and Chromatin Damage (Hardcover, 2018)

Sperm Chromatin: An Overview.- Sperm Nucleoproteins (Histones and Protamines).- Sperm Nuclear Architecture.- Sperm Chromatin Structure Assay (SCSA®): Evolution from Origin to Clinical Utility.- TUNEL Assay.- TUNEL Assay by Bench Top Flow Cytometer in Clinical Laboratories.- The Comet Assay.- Sperm Chromatin Dispersion (SCD) Assay.- Cytochemical Tests of Sperm Chromatin Maturity.- Is There an Optimal Sperm DNA Test?.- Oxidative Stress.- Apoptosis in Ejaculated Spermatozoa and in the Normal and Pathological Testes: Abortive Apoptosis and Sperm Chromatin Damage.- Defective Spermatogenesis and Sperm DNA Damage.- Sperm Chromatin and Lifestyle Factors.- Cancer and Sperm DNA Damage.- Sperm Chromatin and Environmental Factors.- Sperm DNA Damage and Oocyte Repair Capability.- Experimental Studies on Sperm DNA Fragmentation and Reproductive Outcomes.- Sperm DNA and Natural Pregnancy.- Sperm DNA and ART (IUI, IVF, ICSI) Pregnancy.- Sperm DNA and Pregnancy Loss after IVF and ICSI.- Sperm DNA Tests are Clinically Useful: Pro.- Sperm DNA Tests Are Clinically Useful: CON.- Antioxidant Therapy.- Varicocelectomy.- Physiological Intra-Cytoplasmic Sperm Insemination Based on Hyaluronic Acid Binding Ability.- Advanced Sperm Processing / Selection Techniques.- Use of Testicular Sperm for ICSI: Pro.- Debate on the Use of Testicular Sperm for ICSI: Con.- Strategies to Diminish DNA Damage in Sperm Samples used for ART.- Sperm DNA Testing: Where Do We Go from Here?