Handheld Total Chemical and Biological Analysis Systems: Bridging Nmr, Digital Microfluidics, and Semiconductors (Paperback, Softcover Repri)

Chapter 1 Introduction 1.1 Overview 1.2 Global Necessities for In Vitro Diagnostic Tools 1.3 Nuclear Magnetic Resonance for In Vitro Diagnosis 1.4 Organization References Chapter 2 State-of-the-Art CMOS In Vitro Diagnostic Devices 2.1 Introduction 2.2 Transducing Mechanisms of CMOS IVD Tools 2.2.1 Electrical-based 2.2.2 Optical-based 2.2.3 Magnetic-based 2.2.4 Mechanical-based 2.2.5 NMR-based 2.3 In Vitro Diagnostic Applications 2.3.1 Immunoassay 2.3.2 DNA Hybridization Assay 2.3.3 Cell/Bacteria Diagnosis 2.4 Discussions and Selection Guide 2.4.1 Integration Level 2.4.2 Labeling 2.4.3 Hardware Preparation 2.4.4 Operation 2.4.5 Specificityan 2.4.6 Summary References Chapter 3 Electronic-Automated Micro-NMR Assay with DMF Device 3.1 Introduction 3.2 First Prototype: Primary Investigation on NMR-DMF 3.2.1 Discrete Electronics and Back-End Signal Processing 3.2.2 Magnet 3.2.3 RF Coils 3.2.4 DMF Device Fabrication and Actuation 3.2.5 Experimental Results 3.3 Second Prototype: CMOS Micro-NMR Platform with DMF 3.3.1 Design and Implementation of CMOS TRX 3.3.2 Portable Magnet and RF Coil Co-Design 3.3.3 DMF Device and Its Control Circuit 3.3.4 Experimental Results 3.3.5 Discussion and Outlook 3.4 Summary References Chapter 4 One-Chip Micro-NMR Platform with B0-field Stabilization 4.1 Introduction 4.2 Platform Design 4.2.1 Micro-NMR Transceiver 4.2.2 Multi-Functional Planar Coil 4.2.3 Hall Sensor, Readout Circuit and Current Driver 4.3 Prototype and Experimental Results 4.3.1 Experimental Setup and Electrical Measurements 4.3.2 Biological/Chemical Measurements 4.3.3 Comparison and Discussion 4.4 Summary Reference Chapter 5 Conclusion and Outlook 5.1 Summary of Researches 5.2 Future Prospects References Appendix A Modular NMR Electronic Components and Measurement B DMF Device and Electronics C Software and Hardware Interface of Micro-NMR Platform