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· 분류 : 외국도서 > 과학/수학/생태 > 과학 > 화학 > 유기화학
· ISBN : 9783527331857
· 쪽수 : 683쪽
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PPREFACE
INTRODUCTION: MICROWAVE SYNTHESIS IN PERSPECTIVE
Microwave Synthesis and Medicinal Chemistry
Microwave-Assisted Organic Synthesis (MAOS): A Brief History
Scope and Organization of the Book
MICROWAVE THEORY
Microwave Radiation
Microwave Dielectric Heating
Dielectric Properties
Microwave versus Conventional Thermal Heating
Microwave Effects
EQUIPMENT REVIEW
Introduction
Domestic Microwave Ovens
Dedicated Microwave Reactors for Organic Synthesis
Single-Mode Instruments
Multimode Instruments
MICROWAVE PROCESSING TECHNIQUES
Solvent-Free Reactions
Phase-Transfer Catalysis
Open- versus Closed-Vessel Conditions
Pre-pressurized Reaction Vessels
Nonclassical Solvents
Passive Heating Elements
Processing Techniques in Drug Discovery and High-Throughput Synthesis
Scale-Up in Batch and Continuous Flow
LITERATURE SURVEY PART A: TRANSITION METAL-CATALYZED REACTIONS
General Comments
Carbon?Carbon Bond Formations
Carbon?Heteroatom Bond Formations
Other Transition Metal-Mediated Processes
LITERATURE SURVEY PART B: MISCELLANEOUS ORGANIC
Transformations
Rearrangement Reactions
Cycloaddition Reactions
Oxidations
Reductions and Hydrogenations
Mitsunobu Reactions
Glycosylation Reactions and Related Carbohydrate-Based Transformations
Organocatalytic Transformations
Organometallic Transformations (Mg, Zn, and Ti)
Multicomponent Reactions
Alkylation Reactions
Nucleophilic Aromatic Substitutions
Ring-Opening Reactions
Addition and Elimination Reactions
Substitution Reactions
Enamine and Imine Formations
Reductive Aminations
Ester and Amide Formation
Decarboxylation Reactions
Free Radical Reactions
Protection/Deprotection Chemistry
Preparation of Isotopically Labeled Compounds
Miscellaneous Transformations
7 LITERATURE SURVEY PART C: HETEROCYCLE SYNTHESIS
Three-Membered Heterocycles with One Heteroatom
Four-Membered Heterocycles with One Heteroatom
Five-Membered Heterocycles with One Heteroatom
Five-Membered Heterocycles with Two Heteroatoms
Five-Membered Heterocycles with Three Heteroatoms
Five-Membered Heterocycles with Four Heteroatoms
Six-Membered Heterocycles with One Heteroatom
Six-Membered Heterocycles with Two Heteroatoms
Six-Membered Heterocycles with Three Heteroatoms
Larger Heterocyclic and Polycyclic Ring Systems
LITERATURE SURVEY PART D: COMBINATORIAL CHEMISTRY AND HIGH-THROUGHPUT ORGANIC SYNTHESIS
Solid-Phase Organic Synthesis
Soluble Polymer-Supported Synthesis
Fluorous-Phase Organic Synthesis
Grafted Ionic Liquid-Phase-Supported Synthesis
Polymer-Supported Reagents
Polymer-Supported Catalysts
Polymer-Supported Scavengers