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· 분류 : 외국도서 > 건강/스포츠 > 건강 > 알러지
· ISBN : 9783642837579
· 쪽수 : 1318쪽
· 출판일 : 1990-12-22
목차
I Structure and Function of Recognition and Effector Molecules.- The T Cell Receptor Complex.- T Cell Receptors.- Positive and Negative Selection of T Cells: A Transgenic Model.- Selection of an ?? T Cell Antigen Receptor In Vivo and Engineering a Solulizable Form.- Mice Transgenic for the T Cell Receptor C?4 Gene are Altered in T Cell Development.- Lymphocytes Bearing Either ??-TCR or ??-TCR Can Recognize Non-MHC Encoded CD1 Molecules.- Assembly of the T Cell Receptor/CD3 Complex.- MHC and Antigen Presentation.- Structural and Functional Analysis of Human Class I and Class II Major Histocompatibility Complex Proteins, with Special Emphasis on Alloreactivity.- Further Analysis of the Role of MHC Molecules in Antigen Presentation.- Studies on the Nature of Physiologically Processed Antigen.- Role of MHC Polymorphism in Autoimmune Disease.- Complex Regulation of MHC Class I Expression: Constitutive and Modulated Patterns of Expression.- Somatic Changes of Ig and T Cell Receptor Genes.- Organization and Reorganization of Antigen Receptor Genes.- The Human Immunoglobulin Kappa Genes.- Somatic Changes in the Immune Response to the Hapten 2-Phenyl Oxazolone.- The Lymphoid V (D) J Recombination Activity: Studies of Exogenous Plasmid Substrates in Whole Cells.- Early Expression of Ig-Related Genes in the Human B-Cell Lineage.- Cell Interaction Molecules.- Adhesion Receptors Regulate Antigen-Specific Interactions, Localization, and Differentiation in the Immune System.- From Marker Antigens for T Lymphocyte Subsets to Molecules that Regulate Cell Activation.- The T-Cell Antigen Receptor and CD2 in Rat T-Cell Activation and Ontogeny.- Tolerance Induction Using CD4 and CD8 Monoclonal Antibodies.- A Lymphocyte Homing Receptor: A Member of an Emerging Class of Cell Adhesion Molecules.- Complement.- to the Symposium on Complement.- The Regulators of Complement Activation (RCA) Gene Cluster.- Host Cell Protection from Complement by Glycosylphosphatidylinositol- Anchored Complement Inhibitors and Their Deficiencies in Paroxysmal Nocturnal Hemoglobinuria.- Inflammation-Promoting Complement Fragments.- Evasion Strategies of Microorganisms.- Production of Complement Component C3 by Lymphoid Cell Lines: Possible Function of C3 Fragments as Autocrine Growth Regulators.- Protein Phosphorylation as a Mechanism of Resistance Against Complement Damage.- The Mosaic Nature of the Complement Proteins.- II Cell Developments.- Development of T Cells.- 1. Phylogeny, Stem Cells, Lineages.- The Role of the Thymus in the Development of T-Cells.- Ontogeny of T Cells and a Third Lymphocyte Lineage in the Chicken.- Analysis of Hematopoietic Stem Cell Development In Vivo.- Utilization of a Bone Marrow Suspension Culture System for the Analysis and Manipulation of T-Cell Development.- Diversity, Development, Ligands and Probable Functions of ??T Cells.- Thymic Epithelial Cells Induce In Vitro Differentiation of PRO-T Lymphocyte Clones into TCR ?, ?/CD3+ and TCR ?,?/CD3+ Cells.- Expression of T Cell Receptor Associated Proteins During Human T Cell Development.- 2. Repertoire Selection.- Selection of the T Cell Repertoire in the Thymus.- T Cell Differentiation in Lower Vertebrates.- Participation of CD4 and CD8 Accessory Molecules in the Development and Selection of T Lymphocytes.- Development of the T Cell Repertoire: Contributions of Both TCR-MHC and Accessory Molecule-MHC Interactions.- Self-Nonself Discrimination by the Immune System.- Development of B Cells.- 1. Phytogeny, Stem Cells, Lineages.- Development and Regulation of the B Lymphocyte Lineage: An Interpretive Overview.- Control of Expression of Immunoglobulin Genes.- Regulation of Immunoglobulin Gene Rearrangement.- Isolation and Characterization of Hematopoietic Stem Cells and Progenitors.- Structure, Control of Expression and Putative Function of the PreB Cell- Specific Genes VpreB and ?5.- 2. Repertoire Selection.- B Cell Differentiation: Development of Antibody Repertoires.- Evolution of Immunoglobuli