The Evaluation Of Surrogate Endpoints (Hardcover)

Introduction. - Setting the Scene. - Regulatory Aspects in Using Surrogate Markers in Clinical Trials. - Notation and Motivating Studies. - The History of Surrogate Marker Validation. - Validation Using Single-Trial Data: Mixed Binary and Continuous Outcomes. - A Meta-Analytic Validation Framework for Contiuous Outcomes. - The Choice of Units. - Extensions of the Meta-Analytic Approach to Surrogate Endpoints. - Meta-Analytic Validation with Binary Outcomes. - Validation in the Case of Two Failure-Time Endpoints. - An Ordinal Surrogate for a Survival True Endpoint. - A Combination of Longitudinal and Survival Endpoints. - Repeated Measures and Surrogate Marker Validation. - Bayesian Evaluation of Surrogate Endpoints. - Surrogate Marker Validation in Mental Health. - The Evaluation of Surrogate Endpoints in Practice: Experience in HIV. - An Alternative Measure for Meta-Analytic Surrogate Marker Validation. - Discussion: Surrogate Endpoint Definition and Evaluation. - The Promise and Peril of Surrogate End Points in Cancer Research.