Data Monitoring in Clinical Trials: A Case Studies Approach (Paperback)

From the contents: Assessing Possible Late Treatment Effects Early- The Diabetic Retinopathy Study Experience.- Data and Safety Monitoring in the Beta-Blocker Heart Attack Trial- Early Experiences in Formal Monitoring Methods.- Data Monitoring for the Aspirin Component of the Physicians Health Study- Importance of Secondary Outcomes.- Early Termination of the Stroke Prevention in Atrial Fibrillation I Trial- Protecting Participant Interests in the Face of Scientific Uncertainties and the Cruel Play of Chance.- Early Termination of the Diabetes Control and Complications Trial Methodologic Issues.- Data Monitoring in the AIDS Clinical Trials Group Study 981- Conflicting Interim Results.- Challenges in Monitoring the Breast Cancer Prevention Trial.- Costantino andTheodore Colton.- Metoprolol CR/XL Randomized Intervention Trial in Chronic Heart Failure.- Potentially High Risk Treatment in High Risk Patients.- Stopping the Randomized Aldactone Evaluation Study Early for Efficacy.- Data Monitoring in the Heart Outcomes Prevention Evaluation and the Clopidogrel in Unstable Angina to Prevent Recurrent Ischemic Events Trials- Avoiding Important Information Loss.