[eBook Code] Sample Sizes for Clinical, Laboratory and Epidemiology Studies (eBook Code, 4th)

Preface vii

1 Basic Design Considerations 1

2 Further Design Considerations 29

3 Binary Outcomes 41

4 Ordered Categorical Outcomes 55

5 Continuous Outcomes 67

6 Rate Outcomes 83

7 Survival Time Outcomes 99

8 Paired Binary, Ordered Categorical and Continuous Outcomes 117

9 Confidence Intervals 137

10 Repeated Outcome Measures 157

11 Non‐Inferiority and Equivalence 169

12 Cluster Designs 195

13 Stepped Wedge Designs 215

14 More than Two Groups Designs 229

15 Genomic Targets and Dose‐Finding 239

16 Feasibility and Pilot Studies 251

17 Therapeutic Exploratory Trials: Single Arm with Binary Outcomes 269

18 Therapeutic Exploratory Trials: Survival, Dual Endpoints, Randomised and Genomic Targets 283

19 The Correlation Coefficient 305

20 Observer Agreement Studies 317

21 Reference Intervals and Receiver Operating Curves 339

22 Sample Size Software ^SS_S 361

Cumulative References 363

Index 381