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· 분류 : 외국도서 > 과학/수학/생태 > 과학 > 화학 > 공업화학
· ISBN : 9781119300182
· 쪽수 : 488쪽
목차
Ch 1 - Discovery and function of the HGF/MET and the MSP/RON kinase signaling pathways in cancer
Silvia Benvenuti, Melissa Milan, and Paolo Comoglio; Candiolo Cancer Institute, Italy
Ch 2 - The role of HGF/MET and MSP/RON signaling in tumor progression and resistance to anticancer therapy
Lidija Klampfer; ProteXase Therapeutics, Inc., USA
Ben Yaw Owusu; University of Alabama at Birmingham School of Medicine, USA
Ch 3 - HGF Activator (HGFA) and its inhibitors HAI-1 and HAI-2: Key players in tissue repair and cancer
Hiroaki Kataoka and Takeshi Shimomura; University of Miyazaki, Japan
Ch 4 - Physiological Functions and Role of Matriptase in Cancer
Thomas E. Hyland, Karin List, and Fausto A. Varela; Wayne State University, USA
Ch 5 - The cell-surface, transmembrane serine protease Hepsin: discovery, function and role in cancer
Denis Belitskin, Juha Klefström, Shishir Pant, and Topi Tervonen; University of Helsinki, Finland
Ch 6 - Targeting HGF with antibodies as an anticancer therapeutic strategy
Donald Bottaro, Dinuka M De Silva, and Arpita Roy; National Cancer Institute, USA
Ch 7 - MET and RON Receptor Tyrosine Kinases as Therapeutic Antibody Targets for Cancer
Ling Liu, Mark Wortinger, Jonathan Tetreault, and Nick Loizos; Eli Lilly, USA
Ch 8 - Inhibitory antibodies of the proteases HGFA, matriptase, and hepsin
Daniel Kirchoffer, Robert Lazarus, and Charles Eigenbrot; Genentech, USA
Ch 9 - Inhibitors of the growth-factor activating proteases matriptase, hepsin and HGFA: Strategies for rational drug design and optimization
Robert Galemmo; ProteXase Therapeutics, Inc., USA, James Janetka; Washington University, USA
Ch 10 - Cyclic peptide serine protease inhibitors based on the natural product SFTI-1
Ashley Buckle, David E. Hoke, Olga Ilyichova, and Blake T. Riley; Monash University, Australia, Jonathan M. Harris; Queensland University of Technology, Australia
Ch 11 - Screening combinatorial peptide libraries in protease inhibitor drug discovery
Paulina Kasperkiewicz and Marcin Poreba; Sanford Burnham Prebys Medical Discovery Institute, USA, Marcin Drag and Wioletta Rut; Wroclaw University of Technology, Poland
Ch 12 - Chemical probes targeting proteases for imaging and diagnostics in cancer
Pedro Gonçalves and Steven Verhelst; University of Leuven, Belgium
Ch 13 - Cancer Diagnostics of protease activity and metastasis
John Beard and Timothy O’Brien; Stage I Diagnostics, Inc., USA
Ch 14 - Roles of pericellular proteases in tumor angiogenesis: therapeutic implications
Janice Kraniak, Raymond R. Mattingly, and Bonnie Sloane; Wayne State University School, USA