Non-Clinical Vascular Infusion Technology, Volume I : The Science (Paperback)

Body Fluid DynamicsIntroductionComposition and units of measurementCompartmentalization and DistributionMovement between Compartments/ExchangeBody Fluid HomeostasisSummaryReferencesPhysico-Chemical FactorsIntroductionOsmolalityAcid-Base BalanceViscositySurface TensionDiffusionSummary of Infusion ForcesReferencesVascular Infusion DynamicsEssential physiologyIntravenous Delivery Rates and VolumesReferencesFormulation Considerations, Co-author: Kevin SoobenIntroductionFormulation selection strategyStudy design and species/strainThe properties of the compoundStrategies for dealing with poor solubilityUnwanted formulation effectsExcipient toxicityStrategies for dealing with injection site reactions and haemolysisStrategies for dealing with poor stabilitySterilityConclusionReferencesPrestudy analytical assessments: Equipment compatibility, Co-author: James BakerIntroduction Stability of the formulation with the formulation storage vesselCompatibilityChoice of materialReferencesHaemocompatibility, Co-author: Sophie HillIntroductionObjectives.Methods of assessing haemocompatibilityDiscussionConclusionReferencesAnnex: Common excipients and vehicles