Aging at the Molecular Level (Hardcover, 2003)

Editorial: About the series 'Biology of aging and its modulation'; S. Rattan Preface 1. Free radical production and antioxidant defense: a primer; Nicolle Sitte, Thomas von Zglinicki 2. Oxidative DNA damage and repair - implications for aging; Erling Seeberg 3. Oxidative damage to proteins; Nicolle Sitte 4. Ageing rate, mitochondrial free radical production and constitutive sensitivity to lipid peroxidation: insights from comparative studies; Reinald Pamplona, Gustavo Barja 5. Genomic instability in human premature aging; Vilhelm A. Bohr, Patricia L. Opresko 6. Oxidative damage, somatic mutations and cellular aging; Rita A. Busuttil, Miguel Rubio, Martijn E.T. Dolle, Judith Campisi, Jan Vijg 7. Mitochondria and aging; Martin Barron, Doug Turnbull 8. Biological clocks in the aging cell; Petra Boukamp 9. Telomeric damage in aging; Thomas von Zglinicki 10. Probing the in vivo relevance of oxidative stress in aging using knockout and transgenic mice; Florian L. Muller, James Mele, Holly Van Remmen, Arlan Richardson 11. Non-oxidative modification of DNA and proteins; Alan K. Hipkiss 12. Transcriptional and translational dysregulation during aging; Suresh I.S. Rattan 13. Metabolic regulation of gene silencing and life span; Haim Y. Cohen, Kevin J. Bitterman, David A. Sinclair 14. The proteasome in aging; Geraldine Carrard, Bertrand Friguet 15. Aging and lysosomal degradation of cellular constituents; Alexei Terman, Ulf T. Brunk Index