Introduction to Genetic Analysis (10th International Edition, Hardcover)

From the Contents: The Genetics Revolution in the Life Sciences The nature of biological information How information becomes biological form Genetics and evolution Genetics has provided a powerful new approach to biological research Model organisms have been crucial in the genetics revolution Genetics changes society Genetics and the future PART I: TRANSMISSION GENETICS Single-Gene Inheritance Single-gene inheritance patterns The chromosomal basis of single-gene inheritance patterns The molecular basis of Mendelian inheritance patterns Some genes discovered by observing segregation ratios Sex-linked single-gene inheritance patterns Human pedigree analysis Independent Assortment of Genes Mendel's law of independent assortment Working with independent assortment The chromosomal basis of independent assortment Polygenic inheritance Organelle genes: inheritance independent of the nucleus Mapping Eukaryote Chromosomes by Recombination Diagnostics of linkage Mapping by recombinant frequency Mapping with molecular markers Centromere mapping with linear tetrads Using the chi-square test for testing linkage analysis Accounting for unseen multiple crossovers Using recombination-based maps in conjunction with physical maps The molecular mechanism of crossing over The Genetics of Bacteria and Their Viruses Working with microorganisms Bacterial conjugation Bacterial transformation Bacteriophage genetics Transduction Physical maps and linkage maps compared Gene Interaction Interactions between the alleles of a single gene: variations on dominance Interaction of genes in pathways Inferring gene interactions Penetrance and expressivity PART II: FROM DNA TO PHENOTYPE DNA: Structure and Replication DNA: the genetic material The DNA structure Semiconservative replication Overview of DNA replication The replisome: a remarkable replication machine Replication in eukaryotic organisms Telomeres and telomerase: replication termination RNA: Transcription and Processing RNA Transcription Transcription in eukaryotes Intron removal and exon splicing Small functional RNAs that regulate and protect the eukaryotic genome Proteins and Their Synthesis Protein structure The genetic code tRNA: the adapter Ribosomes The proteome Gene Isolation and Manipulation Overview: isolating and amplifying specific gene fragments Generating recombinant DNA molecules Finding a specific clone of interest Determining the base sequence of a DNA segment Aligning genetic and physical maps to isolate specific genes Genetic engineering Regulation of Gene Expression in Bacteria and Their Viruses Gene regulation Discovery of the lac system: negative control Catabolite repression of the lac operon: positive control Dual positive and negative control: the arabinose operon Metabolic pathways and additional levels of regulation: attenuation Bacteriophage life cycles: more regulators, complex operons Alternative sigma factors regulate large sets of genes Regulation of Gene Expression in Eukaryotes Transcriptional regulation in eukaryotes: an overview Lessons from yeast: the GAL system Dynamic chromatin Short-term activation of genes in a chromatin environment Long-term inactivation of genes in a chromatin environment Gender-specific silencing of genes and whole chromosomes Post-transcriptional gene repression by miRNAs (...)