Chemical Modification of Biological Polymers (Hardcover)

Functional groups in Biological Polymers and Factor Governing Reactivity
Identification of Functional Groups
Nucleophilicity and reactivity
Microenvironmental Effects
Solvent Effects
Conformational Issues
Modification of Amino Groups in Proteins
Lysine
Alpha-amino group
Arginine (guanidine group)
Modification of Hydroxyl and Carboxyl Groups in Proteins
Tyrosine
Serine
Threonine
Aspartic acid
Glutamic acid
Modification of Imidazole and Indole Groups in Proteins
Histidine
Tryptophan
Modification of Sulfur-Containing Groups in Proteins
Cysteine
Cystine
Methionine
Modification of Nucleic Acids
Dimethyl sulfate
Periodate oxidation (see under polysaccharides)
Nitrous acid
Hydrazine
Diethylpyrocarbonate
Modification of Polysaccharides
Periodate oxidation (Malaprade reaction)
Alkylation
In Vivo Non-enzymatic chemical modification of biological polymers
Oxidation
4-Hydroxy-2-nonenal
Glycation
Proteomic Methods for the Analysis of the Modification of Biological Polymers
Mass spectrometry
NMR
Chromatography
Chemical Methods for the Preparation of Conjugates of Biological Polymers
Protein conjugates
Protein-matrix (including protein microarrays)